Contemporary Endoscopic Spine Surgery brings the reader the most up-to-date information on the endoscopy of the spine. Key opinion leaders from around the world have come together to present the clinical evidence behind their competitive endoscopic spinal surgery protocols. Chapters in the series cover a range of aspects of spine surgery including spinal pain generators, preoperative workup with modern independent predictors of favorable clinical outcomes with endoscopy, anesthesia in an outpatient setting, management of complications, and a fresh look at technology advances in a historical context. The reader will have a first-row seat during the illustrative discussions of expanded surgical indications from herniated disc to more complex clinical problems, including stenosis, instability, and deformity in patients with advanced degenerative disease of the human spine. Contemporary Endoscopic Spine Surgery is divided into three volumes: Cervical Spine, Lumbar Spine, and Advanced Technologies to capture an accurate snapshot in time of this fast-moving field. It is intended as a comprehensive go-to reference text for surgeons in graduate residency and postgraduate fellowship training programs and for practicing spine surgeons interested in looking for the scientific foundation for expanding their clinical practice towards endoscopic surgery. This volume (Advanced Technologies) covers the following endoscopic spine surgery topics in 19 detailed chapters: endoscopic intradiscal therapy and foraminoplasty, evidence based medicine in spine surgery, artificial intelligence for spine surgery, postoperative management, transforaminal lumbar endoscopy and associated complications, laser applications in full endoscopy of the spine, high frequency surgery for the treatment of herniated discs, lumbar MRI, cost and maintenance management of endoscopic spine systems, regenerative medicine, interbody fusion, endoscopic intravertebral canal decompression after spinal fracture, treatment of lumbar tuberculosis, treatment of degenerative scoliosis, treatment of thoracic meningioma with spinal canal decompression, and cervical endoscopic unilateral laminotomy for bilateral decompression (CE-ULBD).

This reference work provides comprehensive information about diabetic nephropathy. Chapters in the book introduce the reader to the link between diabetes, obesity and chronic kidney disease (CKD) and delve into many topics relevant to treating kidney disease in diabetic patients. These topics include CKD epidemiology, diagnosis, treatment considerations for the elderly patient, post-transplant diabetes, pathophysiology, biomarkers and much more. Special topics such as the incidence of cardiovascular disease in diabetic CKD, nutrition for obese CKD patients and the clinical use of biomarkers for evaluating cases are also included. <p></p> The broad spectrum coverage of informative topics about diabetic kidney disease make this an essential reference for medical students and clinical residents/healthcare professionals in nephrology, endocrinology, geriatrics, internal medicine and general surgery. Researchers interested in the clinical biochemistry of diabetes and associated disorders will also benefit from the information presented.

Diabetes and the Eye familiarizes the reader with the relationship between diabetes mellitus and the visual system. It presents a discussion about the diabetes epidemic and the many ways the disease can cause vision loss, with several types of vision disorders covered in separate chapters. Information about new frontiers in the treatment of ophthalmic disorders is also presented to reflect the advances being made in the clinic. Key features: - presents detailed coverage of vision loss in diabetes in 12 organized and easy to read chapters - includes a discussion on the diabetes epidemic - covers a wide range of vision disorders, of different parts of the eye - includes information on current practices in eye care and management for diabetic patients - includes information about relevant diagnostic tools This book serves as a useful handbook for medical students, residents in ophthalmology, community and academic ophthalmologists, as well as members of the internal medicine and family practice communities.

This 3 volume set offers a comprehensive compilation which presents detailed information about ophthalmic (retinal, vitreous and macular) diseases. Key features of this set include: o Emphasis on practical features of clinical diagnosis o Concise and didactic presentation of key manifestations of diseases designed for rapid reference and target recall o A vast selection of illustrations to sharpen clinical problem-solving skills o Step by step treatment approaches to enhance the reader&rsquo;s ability to handle medical cases o Citations or relevant research articles in each chapter for further reading The second volume of this set covers several choroid and retinal disorders including, commotio retinae, choroidal rupture and macular trauma, retinal breaks and detachment, and a variety of congenital / genetic eye diseases such as Best&rsquo;s disease and Stargardt disease. Written by a group of retina specialists, this book is an excellent resource for knowledge about retinal disorders. The streamlined format and evidence based medicine presented in the volume make this book the perfect reference for medical students, residents, general ophthalmologists and retina specialists.

This 3 volume set offers a comprehensive compilation which presents detailed information about ophthalmic (retinal, vitreous and macular) diseases. Key features of this set include: o Emphasis on practical features of clinical diagnosis o Concise and didactic presentation of key manifestations of diseases designed for rapid reference and target recall o A vast selection of illustrations to sharpen clinical problem-solving skills o Step by step treatment approaches to enhance the reader&rsquo;s ability to handle medical cases o Citations or relevant research articles in each chapter for further reading The third volume of this set covers eye infections (bacterial and viral), inflammatory disorders and neoplasms. Written by a group of retina specialists, this book is an excellent resource for knowledge about retinal disorders. The streamlined format and evidence based medicine presented in the volume make this book the perfect reference for medical students, residents, general ophthalmologists and retina specialists.

Contemporary Scleral Lenses: Theory and Application, provides comprehensive information about scleral lenses. Chapters of this volume have been contributed by renowned scleral lens experts and cover a variety of interesting topics. These topics include the history and evolution of scleral lenses, basic scleral lens structure, optics and customizable features of scleral lenses, analysis of ocular surface shape, ocular surface topography and advances in optometry technology. These topics give readers an explanation of how to utilize diagnostic equipment in optometry practice and enables practitioners to employ a scientific and objective approach to scleral lens fitting. Key features of this volume include: - A straightforward approach to ophthalmic examination flow, evaluation and documentation - A review of Scleral lens care and handling - Descriptions of a variety of complex medical and ocular indications for scleral lenses - Strategic tips to promote your own scleral lens practice - A unique perspective of esteemed corneal specialists regarding the collaborative care of the patient This textbook is a suitable reference for ophthalmology students and practitioners. This text will assist practitioners in enhancing their scleral lens practice by providing them useful information for improving patient vision, ocular surface rehabilitation and quality of life.

PCR (Polymerase Chain Reaction) technology has become an indispensable component of routine veterinary diagnostics. However, a number of pitfalls and limiting factors affect its sensitivity and specificity of detection. It is imperative that veterinary PCR diagnosticians include such considerations in their work. Extensive experience with PCR technology in both research and diagnostic applications enables researchers to pinpoint these practical limitations, and therefore instruct the user in approaches that avoid these common errors. This E-book discusses the basic concepts, chemistries, and instrumentation of standard and real-time PCR, and includes present applications and future perspectives for veterinary diagnostics. Critical pitfalls have been highlighted in this text with regard to veterinary PCR diagnostics which include: i) choice of platform technologies for PCR diagnosis; ii) construction of optimized PCR primers and probes to ensure its highest specificity and sensitivity; iii) correct sampling and efficient methods to preserve and release nucleic acids; iv) maximization of PCR amplification efficiency; and v) avoidance and monitoring of contamination in Veterinary PCR Diagnostics. This eBook should be a valuable reference for all veterinary professionals interested in this modern diagnostic tool.

A multidisciplinary approach is increasingly being adapted by the Pharmaceutical industry to tackle several challenges in developing efficacious treatment solutions. The field of Ophthalmology is no less different. Treatise on Ocular Drug Delivery is a unique collection of information put together by various experts in the field. One of the major goals behind this volume is to link clinical information with the current strategies employed in ocular drug delivery. This monograph covers a range of topics on ocular pharmacology. Chapters in the e-book cover several aspects of drug delivery research such as the biochemical background of specific eye diseases, challenges for ocular drug delivery, the role of influx and efflux transporters, novel drug delivery systems, pharmacokinetics, regulatory aspects, and patenting opportunities for researchers. This E-Book would serve as a suitable reference for pharmacy graduates, medical students, professional scientists and ophthalmic clinicians in academic and industrial laboratories.

The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data from their own labs and provided a perspective relevant to specific neurological diseases and potential drug targets. Historically, the transcription factor cAMP response element-binding (CREB) has been the most well documented transcription factor shown to play a role in memory. CREB has several functions, but its most notable function has to do with the formation of long-term memories. More recently, other transcription factors, such as C/EBP, Egr protein, AP-1, and NF-&amp;kappa;B have been implicated in memory as well. Of these, scientific literature on NF-&amp;kappa;B&amp;rsquo;s theorized role in synaptic plasticity and memory is growing rapidly. Interestingly, in some recent studies CREB and NF-&amp;kappa;B have also been shown to interact with each other where both contribute in a cooperative fashion to the initiation of gene expression.