Recent Advances in Chitosan Films for Controlled Release of Drugs

Luciano      N. Mengatto; Ignacio      M. Helbling; Julio      A. Luna

Abstract

Chitosan is a versatile carrier for biologically active agent from a small molecule such as an antibiotic to macromolecules such as proteins and nucleic acids. In addition, drug delivery devices based on chitosan can be available in a variety of morphologies including films, fibers, nanoparticles and microspheres. Otherwise the inherent advantages of this polymer such as biocompatibility, tissue adhesions and hydrophilic nature, chitosan can be modified to accomplish a specific purpose, for example improves release kinetics. In this review, recent patents of chitosan-based film systems for drug delivery are presented and discussed. This review include matrix type systems, membrane coated systems and film forming solution. For each one of these systems, several examples of manufacture processes, bioactive agents to be delivered and specifics applications are considered. This work highlights the use of chitosan in the film technology for drug delivery, presenting examples of chitosan used in an unmodified state and examples of modifications of the polymer backbone.

Keywords: Chitosan film, chitosan modification, drug delivery, film forming solution, matrix systems, membrane coated systems, "Unmodified CHT Systems", Excipients, Membrane Coated Systems, Film Forming Solutions