Advancements in Anticancer Drug Delivery
Pp. 287-314 (28)
Hemant K.S. Yadav, Abrar E. Srouji, Alyazya Mohammed and Manar Dibi
Cancer is considered one of the leading causes of death worldwide. Over the
past few decades, researchers have worked reluctantly to discover anti-cancer agents
that have saved millions of lives. However, the devastating statistics of increasing
mortality due to cancer every year explain the continuous research in this field, to
figure out newer agents and approaches for fighting cancer. This chapter will discuss
some new drugs discovered which have the ability to effectively target cancer cells
including, avelumab, neratinib, niraparib, durvalumab, nivolumab, Erleada and others
along with their applications in treatment of various types of cancer like, skin, breast,
ovarian, prostate, urothelial etc. Additionally, the chapter will discuss newly adopted
strategies in cancer therapy through antibody-drug conjugates and the utilization of
some already established non-cancer agents with a potential anti-cancer effect, such as
NSAIDs, statins and antidiabetics. Moreover, some new combinations of known anticancer
agents have shown additional benefits with significant results that will be
further discussed in this chapter as well.
Apoptosis, Anti-Cancer Agents, Antibody-Drug Conjugates,
Combination Therapy, Cell Proliferation, Overall Response Rate, Progression-
Free Survival, Repurposing.
Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences University, UAE.