Abstract
Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.
Keywords: Carbohydrates, combinatorial chemistry, carbohydrate scaffolds, mimetics
Mini-Reviews in Medicinal Chemistry
Title: Carbohydrate-Based Scaffolds in Drug Discovery
Volume: 6 Issue: 12
Author(s): Bernd Becker, Glenn C. Condie, Giang Thanh Le and Wim Meutermans
Affiliation:
Keywords: Carbohydrates, combinatorial chemistry, carbohydrate scaffolds, mimetics
Abstract: Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.
Export Options
About this article
Cite this article as:
Becker Bernd, Condie C. Glenn, Thanh Le Giang and Meutermans Wim, Carbohydrate-Based Scaffolds in Drug Discovery, Mini-Reviews in Medicinal Chemistry 2006; 6 (12) . https://dx.doi.org/10.2174/138955706778993003
DOI https://dx.doi.org/10.2174/138955706778993003 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
CB2 Receptor Ligands
Mini-Reviews in Medicinal Chemistry Applications, Properties and Synthesis of ω-Functionalized n-Alkanethiols and Disulfides - the Building Blocks of Self-Assembled Monolayers
Current Organic Chemistry Palladacycles as Antimicrobial Agents
Current Medicinal Chemistry in vitro Anti-leukaemia Activity of Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs)
Recent Patents on Anti-Cancer Drug Discovery Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability
Current Neuropharmacology Convalescent Plasma the Experience and Journey from Blockbuster to Incognito: A Single Centre Experience
Recent Advances in Anti-Infective Drug Discovery Mechanisms Involved in the Genesis of Diabetic Nephropathy
Current Diabetes Reviews Anti-Inflammatory Effects of Alkaline Phosphatase in Coronary Artery Bypass Surgery with Cardiopulmonary Bypass
Recent Patents on Inflammation & Allergy Drug Discovery Energy Remodeling, Mitochondrial Disorder and Heart Failure
Current Pharmaceutical Design Synthesis of Chalcone Derivatives and Their Effects on Proliferation and Tubulin Dynamics Instability of HT-29 Cells
Letters in Drug Design & Discovery Secondary Metabolites from Cyanobacteria: Complex Structures and Powerful Bioactivities
Current Organic Chemistry The Emergence of Novel Coronavirus Disease, Global Treatment Update and its Containment Strategies in Overpopulated Countries: A Review
Coronaviruses Glutamate Binding-Site Ligands of NMDA Receptors
Current Medicinal Chemistry A Critical Appraisal of the Risk of Bias in Systematic Reviews and Metaanalyses Pertaining to COVID-19
Coronaviruses The Two fACEs of the Tissue Renin-Angiotensin Systems: Implication in Cardiovascular Diseases
Current Pharmaceutical Design Structural Bioinformatics Used to Predict the Protein Targets of Remdesivir and Flavones in SARS-CoV-2 Infection
Medicinal Chemistry Modified Nucleotides for Chemical and Enzymatic Synthesis of Therapeutic RNA
Current Medicinal Chemistry Colloidal and Pharmacological Activity of Albumin in Clinical Fluid Management:Recent Developments
Current Drug Therapy On the Psychotropic Effects of Carbon Dioxide
Current Pharmaceutical Design Global Gene Expression in Classification, Pathogenetic Understanding and Identification of Therapeutic Targets in Acute Myeloid Leukemia
Current Pharmaceutical Biotechnology