Abstract
Heart failure (HF) is a major global problem in public health with no curative treatment currently available. Energy remodeling is one of the features in HF, preceding cardiac structure remodeling. As an important energy organelle, mitochondrion plays critical roles in the progress of HF. This review focuses on the potential mechanisms linking mitochondrial functions and energy remodeling in HF including the energy starvation theory and energy substrate metabolism. It also highlights the potentials of novel drugs targeting HF energy metabolism.
Keywords: Energy metabolism, mitochondrial disorder, heart failure.
Current Pharmaceutical Design
Title:Energy Remodeling, Mitochondrial Disorder and Heart Failure
Volume: 22 Issue: 31
Author(s): Peng Wang, Lei Xu and Aijun Sun
Affiliation:
Keywords: Energy metabolism, mitochondrial disorder, heart failure.
Abstract: Heart failure (HF) is a major global problem in public health with no curative treatment currently available. Energy remodeling is one of the features in HF, preceding cardiac structure remodeling. As an important energy organelle, mitochondrion plays critical roles in the progress of HF. This review focuses on the potential mechanisms linking mitochondrial functions and energy remodeling in HF including the energy starvation theory and energy substrate metabolism. It also highlights the potentials of novel drugs targeting HF energy metabolism.
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Cite this article as:
Wang Peng, Xu Lei and Sun Aijun, Energy Remodeling, Mitochondrial Disorder and Heart Failure, Current Pharmaceutical Design 2016; 22 (31) . https://dx.doi.org/10.2174/1381612822666160708224330
DOI https://dx.doi.org/10.2174/1381612822666160708224330 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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