Abstract
Previously, we showed that extracts of ripe seasonal sweet corn tassels possess anti-irritant and anti-oxidant activities. The chemical identification of corn tassel bioactives was investigated by HPLC analysis. The hydroalcoholic extracts are composed primarily ( > 85%) phenolic-type compounds. The predominant component from C18 columns were concentrated by reverse phase chromatography and purified to greater than 97-99% by preparative HPLC chromatography. The chemical was determined by mass and NMR spectrometry to be 4-hydroxy-1-oxindole-3-acetic acid (Tasselin A) with a M.W of 207 daltons. Purified Tasselin A inhibits melanin production in sporulating cultures of the common bread mold. An anti-tyrosinase enzyme assay showed that it inhibits mushroom tyrosinase enzyme (IC50 = 0.75mM), and has both antioxidant, and skin anti-irritant activities. There are no prior reports of bioactives derived from corn tassels with potential skin whitening activity, nor are any corn tassel bioactivities currently employed as ingredients in personal care or skin care products.
Keywords: Anti-tyrosinase, bioactives, corn tassels, 4-hydroxy-2-oxindole-3-acetic acid, melanin inhibitor, skin whitener, HPLC, kojic acid, tasselin A, anti-irritant
Current Bioactive Compounds
Title: Bioactives Derived from Ripe Corn Tassels: A Possible New Natural Skin Whitener, 4-Hydroxy-1-Oxindole-3-Acetic Acid
Volume: 7 Issue: 2
Author(s): John J. Wille and Mark A. Berhow
Affiliation:
Keywords: Anti-tyrosinase, bioactives, corn tassels, 4-hydroxy-2-oxindole-3-acetic acid, melanin inhibitor, skin whitener, HPLC, kojic acid, tasselin A, anti-irritant
Abstract: Previously, we showed that extracts of ripe seasonal sweet corn tassels possess anti-irritant and anti-oxidant activities. The chemical identification of corn tassel bioactives was investigated by HPLC analysis. The hydroalcoholic extracts are composed primarily ( > 85%) phenolic-type compounds. The predominant component from C18 columns were concentrated by reverse phase chromatography and purified to greater than 97-99% by preparative HPLC chromatography. The chemical was determined by mass and NMR spectrometry to be 4-hydroxy-1-oxindole-3-acetic acid (Tasselin A) with a M.W of 207 daltons. Purified Tasselin A inhibits melanin production in sporulating cultures of the common bread mold. An anti-tyrosinase enzyme assay showed that it inhibits mushroom tyrosinase enzyme (IC50 = 0.75mM), and has both antioxidant, and skin anti-irritant activities. There are no prior reports of bioactives derived from corn tassels with potential skin whitening activity, nor are any corn tassel bioactivities currently employed as ingredients in personal care or skin care products.
Export Options
About this article
Cite this article as:
J. Wille John and A. Berhow Mark, Bioactives Derived from Ripe Corn Tassels: A Possible New Natural Skin Whitener, 4-Hydroxy-1-Oxindole-3-Acetic Acid, Current Bioactive Compounds 2011; 7 (2) . https://dx.doi.org/10.2174/157340711796011115
DOI https://dx.doi.org/10.2174/157340711796011115 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Insights into Targeting NEMO for Pharmacological Regulation
Current Drug Targets Induction of Apoptotic Cell Death in Tumor Cells by S100A8/A9 Released from Inflammatory Cells Upon Cellular Activation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Glial Reaction in Parkinsons Diseases: Inflammatory Activation Signaling of Glia as a Potential Therapeutic Target
Current Signal Transduction Therapy Human Interleukin-19: Structure, Function and Disease Associations
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Cellular Changes, Molecular Pathways and the Immune System Following Photodynamic Treatment
Current Medicinal Chemistry Editorial (Thematic Issue: “Current Trend in Oncolytic Virus Therapy Against Cancers”)
Current Cancer Therapy Reviews Engineered Nanoparticles Against MDR in Cancer: The State of the Art and its Prospective
Current Pharmaceutical Design Astrocytes: Adhesion Molecules and Immunomodulation
Current Drug Targets Arachidonic Acid Induces the Migration of MDA-MB-231 Cells by Activating Raft-associated Leukotriene B4 Receptors
Clinical Cancer Drugs Phenolic Compounds in Prevention and Treatment of Skin Cancers: A Review
Current Medicinal Chemistry Controlled Drug Delivery Using Microdevices
Current Pharmaceutical Biotechnology Discussion on Pharmacogenetic Interaction in G6PD Deficiency and Methods to Identify Potential Hemolytic Drugs
Cardiovascular & Hematological Disorders-Drug Targets Structure-Activity Relationships of Flavonoids
Current Organic Chemistry Approaches for the Inhibition of Human Telomerase Based on the Use of Peptide Nucleic Acids and Hammerhead Ribozymes
Mini-Reviews in Medicinal Chemistry Impacts of Amine Functionalized Iron Oxide Nanoparticles on HepG2 Cell Line
Current Nanoscience Clinical Pharmacokinetics of Irinotecan-Based Chemotherapy in Colorectal Cancer Patients
Current Clinical Pharmacology An Association between MicroRNA-21 Expression and Vitamin D Deficiency in Coronary Artery Disease
MicroRNA Episcleritis and Scleritis in Rheumatic Disease
Current Rheumatology Reviews 68Ga/64Cu PSMA Bio-Distribution in Prostate Cancer Patients: Potential Pitfalls for Different Tracers
Current Radiopharmaceuticals Natural Products with Antiangiogenic and Antivasculogenic Mimicry Activity
Mini-Reviews in Medicinal Chemistry