Abstract
Recent advances in growth factor therapy for the treatment of ischemic disease of the heart and peripheral vasculature offer hope for a novel strategy that is based on the generation of a new blood supply. Members of the fibroblast growth factor and vascular endothelial growth factor families and several other molecules have all been shown to induce significant angiogenesis in animal models of acute or chronic, myocardial or peripheral ischemia. In addition, it is known that arteries from specific regions in the arterial tree have various developmental origins. This may be one explanation for why arteries of different parts of the arterial tree undergo differential changes during the pathogenesis of vascular disease. There is speculation over several fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation. Here we discuss what is known to date about the differential developmental origin of arteries and the possible consequences for therapeutic angiogenesis.
Keywords: ischemic disease, fibroblast growth, disrupted cell contact, hematopoietic progenitors, smooth muscle cells, mesodermal tissue, cytoskeletal markers desmin, vascular endothelial cells, mesenchymal transition failures, angiogenic processes
Current Medicinal Chemistry
Title: Vasculogenesis and Angiogenesis Depend on the Developmental Origin in the Arterial Tree
Volume: 9 Issue: 17
Author(s): Masumi Shimizu, Jaroslav Pelisek and Sigrid Nikol
Affiliation:
Keywords: ischemic disease, fibroblast growth, disrupted cell contact, hematopoietic progenitors, smooth muscle cells, mesodermal tissue, cytoskeletal markers desmin, vascular endothelial cells, mesenchymal transition failures, angiogenic processes
Abstract: Recent advances in growth factor therapy for the treatment of ischemic disease of the heart and peripheral vasculature offer hope for a novel strategy that is based on the generation of a new blood supply. Members of the fibroblast growth factor and vascular endothelial growth factor families and several other molecules have all been shown to induce significant angiogenesis in animal models of acute or chronic, myocardial or peripheral ischemia. In addition, it is known that arteries from specific regions in the arterial tree have various developmental origins. This may be one explanation for why arteries of different parts of the arterial tree undergo differential changes during the pathogenesis of vascular disease. There is speculation over several fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation. Here we discuss what is known to date about the differential developmental origin of arteries and the possible consequences for therapeutic angiogenesis.
Export Options
About this article
Cite this article as:
Shimizu Masumi, Pelisek Jaroslav and Nikol Sigrid, Vasculogenesis and Angiogenesis Depend on the Developmental Origin in the Arterial Tree, Current Medicinal Chemistry 2002; 9 (17) . https://dx.doi.org/10.2174/0929867023369321
DOI https://dx.doi.org/10.2174/0929867023369321 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Metabolic Syndrome, Mild Cognitive Impairment and Dementia
Current Alzheimer Research Transcriptional Control of Metabolism, Inflammation and the Immune Response: The Role of PPARs
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Treatment of Atherosclerotic Renovascular Disease
Current Hypertension Reviews Calcium Antagonists: A Ready Prescription for Treating Infectious Diseases?
Current Topics in Medicinal Chemistry Let Them Eat Cake
Current Nutrition & Food Science Leptin as Clinical Target
Recent Patents on Inflammation & Allergy Drug Discovery Cytomegalovirus Infection in Pediatric Immunocompromised Hosts
Infectious Disorders - Drug Targets The Hot and Potential Targets of Type 2 Diabetes Mellitus Treatment in Recent Decade
Current Drug Targets Role of Asymmetric Dimethylarginine (ADMA) in Diabetic Vascular Complications
Current Pharmaceutical Design Cardiovascular Effects of Methotrexate in Rheumatoid Arthritis Revisited
Current Medicinal Chemistry Omega-3 Fatty Acids: Role in Metabolism and Cardiovascular Disease
Current Pharmaceutical Design Late Effects in Survivors of Childhood CNS Tumors: Review of Results From the Two Largest Survivorship Cooperative Groups
Current Cancer Therapy Reviews Chronic Kidney Disease and the Risk of Cardiovascular Disease Events: A Community-Based Approach
Vascular Disease Prevention (Discontinued) Recent Advances in Health Promoting Effect of Dietary Polyphenols
Current Nutrition & Food Science Prognostic Significance of Asymptomatic Myocardial Ischemia in Women vs. Men
Current Pharmaceutical Design Genetics of Congenital Heart Disease
Current Cardiology Reviews Acute Coronary Syndromes in Patients with Atrial Fibrillation and Heart Failure. Could Novel Oral Anticoagulants be the Solution of the Optimal Antithrombotic Therapy Puzzle?
Cardiovascular & Hematological Agents in Medicinal Chemistry Family History and Preclinical Atherosclerosis
Current Hypertension Reviews Polypharmacy in Cardiovascular Medicine: Problems and Promises!
Cardiovascular & Hematological Agents in Medicinal Chemistry Tartaric Acid Enhances Adrenergic Receptor Activity: Test of a General Theory of Extracellular Aminergic GPCR Enhancer Discovery
Current Drug Discovery Technologies