Abstract
Our interest has been centered on isoquinoline alkaloids obtained from Argemone mexicana (Papaveraceae), Aristolochia constricta (Aristolochiaceae) and the opium alkaloid, papaverine. In this respect, the effect of these isoquinoline alkaloids was investigated on contractions induced by naloxone of isolated guinea pig ileum acutely exposed to morphine in vitro. The activity of these alkaloids was compared to the control compound, papaverine. Furthermore, the effect of these isoquinoline alkaloids was also determined on naloxone-precipitated withdrawal in isolated guinea pig ileum exposed to DAMGO (highly selective mu opioid receptor agonist) and U50-488H (highly selective kappa opioid receptor agonist) to test whether the possible interaction of isoquinoline alkaloids on opioid withdrawal involves muand/ or kappa-opioid receptors. Isoquinoline alkaloids from A. mexicana (from 5x10-6 to 1x10-4 M), from A. constricta (1x10 -5-5x10 -5-1x10 -4 M) as well as papaverine treatment (1x10 -7-5x10 -6-1x10 -6 M) before or after the opioid agonists were able of both preventing and reversing the naloxone-induced contraction after exposure to mu(morphine and DAMGO) or kappa (U50-488H) opiate receptor agonists in a concentration-dependent manner. Both acetylcholine response and electrical stimulation were also reduced by isoquinoline alkaloids and papaverine treatment as well as the final opiate withdrawal was still reduced. The results of the present study indicate that isoquinoline alkaloids as well as papaverine were able to produce significant influence on the opiate withdrawal in vitro and these compounds were able to exert their effects both at muand kappa opioid agonists.
Keywords: Papaverine, isoquinoline alkaloids, Argemone mexicana, Aristolochia constricta, opiate withdrawal, guinea pig ileum
Current Medicinal Chemistry
Title: The Effect of Isoquinoline Alkaloids on Opiate Withdrawal
Volume: 13 Issue: 7
Author(s): A. Capasso, S. Piacente, N. D. Tommasi, L. Rastrelli and C. Pizza
Affiliation:
Keywords: Papaverine, isoquinoline alkaloids, Argemone mexicana, Aristolochia constricta, opiate withdrawal, guinea pig ileum
Abstract: Our interest has been centered on isoquinoline alkaloids obtained from Argemone mexicana (Papaveraceae), Aristolochia constricta (Aristolochiaceae) and the opium alkaloid, papaverine. In this respect, the effect of these isoquinoline alkaloids was investigated on contractions induced by naloxone of isolated guinea pig ileum acutely exposed to morphine in vitro. The activity of these alkaloids was compared to the control compound, papaverine. Furthermore, the effect of these isoquinoline alkaloids was also determined on naloxone-precipitated withdrawal in isolated guinea pig ileum exposed to DAMGO (highly selective mu opioid receptor agonist) and U50-488H (highly selective kappa opioid receptor agonist) to test whether the possible interaction of isoquinoline alkaloids on opioid withdrawal involves muand/ or kappa-opioid receptors. Isoquinoline alkaloids from A. mexicana (from 5x10-6 to 1x10-4 M), from A. constricta (1x10 -5-5x10 -5-1x10 -4 M) as well as papaverine treatment (1x10 -7-5x10 -6-1x10 -6 M) before or after the opioid agonists were able of both preventing and reversing the naloxone-induced contraction after exposure to mu(morphine and DAMGO) or kappa (U50-488H) opiate receptor agonists in a concentration-dependent manner. Both acetylcholine response and electrical stimulation were also reduced by isoquinoline alkaloids and papaverine treatment as well as the final opiate withdrawal was still reduced. The results of the present study indicate that isoquinoline alkaloids as well as papaverine were able to produce significant influence on the opiate withdrawal in vitro and these compounds were able to exert their effects both at muand kappa opioid agonists.
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Cite this article as:
Capasso A., Piacente S., Tommasi D. N., Rastrelli L. and Pizza C., The Effect of Isoquinoline Alkaloids on Opiate Withdrawal, Current Medicinal Chemistry 2006; 13 (7) . https://dx.doi.org/10.2174/092986706776055616
DOI https://dx.doi.org/10.2174/092986706776055616 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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