Abstract
The Horner-Wadsworth-Emmons reaction is one of the most reliable and widespread synthetic tools for the stereocontrolled construction of ethylenic bonds. The versatility of the reaction makes it a valuable synthetic tool to prepare simple as well as densely functionalized and complex molecular scaffolds. This review is devoted to the recent evolution of the reaction, which considerably widens its product scope and synthetic potential. The main recent developments on the HWE reaction presented in this work comprise novel phosphonate reagents and sequential reactions involving the HWE olefination. Interesting applications, including access to challenging or complex synthetic targets, relevant organic compounds and natural products are also highlighted.
Keywords: Horner-Wadsworth-Emmons reaction, carbonyl olefinations, functionalized phosphonate reagents, functionalized olefins, one-pot reactions, tandem reactions.
Current Organic Chemistry
Title:Recent Progress in the Horner-Wadsworth-Emmons Reaction
Volume: 19 Issue: 9
Author(s): Juan A. Bisceglia and Liliana R. Orelli
Affiliation:
Keywords: Horner-Wadsworth-Emmons reaction, carbonyl olefinations, functionalized phosphonate reagents, functionalized olefins, one-pot reactions, tandem reactions.
Abstract: The Horner-Wadsworth-Emmons reaction is one of the most reliable and widespread synthetic tools for the stereocontrolled construction of ethylenic bonds. The versatility of the reaction makes it a valuable synthetic tool to prepare simple as well as densely functionalized and complex molecular scaffolds. This review is devoted to the recent evolution of the reaction, which considerably widens its product scope and synthetic potential. The main recent developments on the HWE reaction presented in this work comprise novel phosphonate reagents and sequential reactions involving the HWE olefination. Interesting applications, including access to challenging or complex synthetic targets, relevant organic compounds and natural products are also highlighted.
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Cite this article as:
A. Bisceglia Juan and R. Orelli Liliana, Recent Progress in the Horner-Wadsworth-Emmons Reaction, Current Organic Chemistry 2015; 19 (9) . https://dx.doi.org/10.2174/1385272819666150311231006
DOI https://dx.doi.org/10.2174/1385272819666150311231006 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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