Abstract
Active quassinoids extracted from Brucea javanica seeds were tested for their activities against Tobacco mosaic virus (TMV). Results from activity-guided assays indicated that the compounds can reduce the replication of the virus by up to 98.5% (50 µg/mL). The active quassinoids inhibit the replication of TMV genomic and subgenomic RNAs and the synthesis of TMV coat protein in vivo but did not destroy the integrality of the virus. Structure-activity relationship (SAR) analysis indicated that the positions of the furan ring, the α,β-conjugated ketone, and integrity of the A ring had significant impacts on the antiviral activity of quassinoids.
Keywords: Simaroubaceae, Brucea javanica, quassinoids, inhibition, TMV, SAR.
Current Bioactive Compounds
Title:Quassinoids from Brucea Javanica Seeds Inhibiting the Replication of Tobacco Mosaic Virus
Volume: 9 Issue: 3
Author(s): Zheng-Kun Zhang, Ming-An Ouyang, Jia-Sui Zhan and Zu-Jian Wu
Affiliation:
Keywords: Simaroubaceae, Brucea javanica, quassinoids, inhibition, TMV, SAR.
Abstract: Active quassinoids extracted from Brucea javanica seeds were tested for their activities against Tobacco mosaic virus (TMV). Results from activity-guided assays indicated that the compounds can reduce the replication of the virus by up to 98.5% (50 µg/mL). The active quassinoids inhibit the replication of TMV genomic and subgenomic RNAs and the synthesis of TMV coat protein in vivo but did not destroy the integrality of the virus. Structure-activity relationship (SAR) analysis indicated that the positions of the furan ring, the α,β-conjugated ketone, and integrity of the A ring had significant impacts on the antiviral activity of quassinoids.
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Zhang Zheng-Kun, Ouyang Ming-An, Zhan Jia-Sui and Wu Zu-Jian, Quassinoids from Brucea Javanica Seeds Inhibiting the Replication of Tobacco Mosaic Virus, Current Bioactive Compounds 2013; 9 (3) . https://dx.doi.org/10.2174/15734072113099990013
DOI https://dx.doi.org/10.2174/15734072113099990013 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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