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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

The Insights and Perspectives of Nitric Oxide-mediated Biofilm Eradication

Author(s): Mingke Yuan, Tao Sun, Jianbing Wu, Yue Fei, Yueqi Yang, Yong Ling, Yihua Zhang and Zhangjian Huang*

Volume 21, Issue 24, 2021

Published on: 01 July, 2021

Page: [2213 - 2229] Pages: 17

DOI: 10.2174/1568026621666210701113043

Price: $65

Abstract

Biofilms are among the most important causes of nosocomial and recurrent infections as biofilms confer antibiotic resistance to pathogenic bacteria and protect them from the host’s immune system. Thus, it is imperative to investigate effective therapeutic agents to counteract biofilms. As an important signaling molecule, Nitric Oxide (NO) plays a crucial role in various biological and pathological processes. NO could disperse biofilm and restore the drug sensitivity by reducing intracellular cyclic-diguanosine monophosphate (c-di-GMP) levels. This review highlights recent advances on antibacterial and antibiofilm effects of NO when NO was co-administered with other antimicrobial agents. A significant improvement in drug permeability and biofilm cell targeting and reduced cytotoxicity could be attained with this strategy. In this review, we briefly lay out challenges and propose future directions in this appealing avenue of research on NO-based therapy for biofilm eradication.

Keywords: Nitric oxide (NO), Biofilm eradication, Antibiotic resistance, Bis-(3′-5′)-cyclic-diguanosine monophosphate (c-di- GMP), Antibacterial therapy, Pathogenic infection.

Graphical Abstract

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