Abstract
Recent evidence suggests that vascular inflammation plays important role in the pathogenesis and the clinical evolution of atherosclerosis. Several circulating inflammatory biomarkers such as acute phase proteins, adhesion molecules and pro-inflammatory cytokines along with biomarkers, proposed the last few years, have clarified the role of inflammation in atherosclerosis. In particular a number of studies have focused on the positive predictive role of C-reactive protein in populations without prior cardiovascular disease. As regards to fibrinogen studies have shown a positive role in predicting cardiovascular events. However, the potential prognostic role of adhesion molecules and cytokines for cardiovascular events is unclear. Thus, further studies are required to evaluate the predictive role of such molecules, as well as others under investigation in states of atherosclerosis.
Keywords: Inflammatory biomarkers, atherosclerosis, coronary artery disease, vascular
Current Medicinal Chemistry
Title: Inflammatory Biomarkers Predicting Events in Atherosclerosis
Volume: 17 Issue: 16
Author(s): E. Stefanadi, D. Tousoulis, N. Papageorgiou, A. Briasoulis and C. Stefanadis
Affiliation:
Keywords: Inflammatory biomarkers, atherosclerosis, coronary artery disease, vascular
Abstract: Recent evidence suggests that vascular inflammation plays important role in the pathogenesis and the clinical evolution of atherosclerosis. Several circulating inflammatory biomarkers such as acute phase proteins, adhesion molecules and pro-inflammatory cytokines along with biomarkers, proposed the last few years, have clarified the role of inflammation in atherosclerosis. In particular a number of studies have focused on the positive predictive role of C-reactive protein in populations without prior cardiovascular disease. As regards to fibrinogen studies have shown a positive role in predicting cardiovascular events. However, the potential prognostic role of adhesion molecules and cytokines for cardiovascular events is unclear. Thus, further studies are required to evaluate the predictive role of such molecules, as well as others under investigation in states of atherosclerosis.
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Cite this article as:
Stefanadi E., Tousoulis D., Papageorgiou N., Briasoulis A. and Stefanadis C., Inflammatory Biomarkers Predicting Events in Atherosclerosis, Current Medicinal Chemistry 2010; 17 (16) . https://dx.doi.org/10.2174/092986710791111288
DOI https://dx.doi.org/10.2174/092986710791111288 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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