Abstract
This paper describes a method for voriconazole assay in pharmaceuticals by using differential pulse polarography (DPP). The voriconazole standard was obtained from pharmaceutical formulations and its purity determined by LC/UV, LC/ESI/MS and DSC analyses. In the DPP analysis a well defined peak (-1.01 V, vs. Ag/AgCl), useful for an accurate and precise assay, was obtained using a 0.01 M KH2PO4 water solution (pH 4.5) as supporting electrolyte. The analytical procedure was successfully applied to the voriconazole determination in tablets and injectables.
Keywords: Voriconazole, Vfend, DPP, Tablets, Injectables, Quantitative analysis
Current Analytical Chemistry
Title: Polarographic Determination of Voriconazole in Pharmaceutical Formulations
Volume: 5 Issue: 3
Author(s): Gianfranco Corbini, Assunta Zanfini, Caterina La Rosa, Alessandro D'Arpino, Racheleb Meucci and Elena Dreassi
Affiliation:
Keywords: Voriconazole, Vfend, DPP, Tablets, Injectables, Quantitative analysis
Abstract: This paper describes a method for voriconazole assay in pharmaceuticals by using differential pulse polarography (DPP). The voriconazole standard was obtained from pharmaceutical formulations and its purity determined by LC/UV, LC/ESI/MS and DSC analyses. In the DPP analysis a well defined peak (-1.01 V, vs. Ag/AgCl), useful for an accurate and precise assay, was obtained using a 0.01 M KH2PO4 water solution (pH 4.5) as supporting electrolyte. The analytical procedure was successfully applied to the voriconazole determination in tablets and injectables.
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Cite this article as:
Corbini Gianfranco, Zanfini Assunta, Rosa La Caterina, D'Arpino Alessandro, Meucci Racheleb and Dreassi Elena, Polarographic Determination of Voriconazole in Pharmaceutical Formulations, Current Analytical Chemistry 2009; 5 (3) . https://dx.doi.org/10.2174/157341109788680282
DOI https://dx.doi.org/10.2174/157341109788680282 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
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