Abstract
This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds.
Keywords: lead compound, isosterism, antagonist, pharmacodynamic, pharmacokinetic, hplc, prostaglandin-h synthase-2 (pghs-
Current Medicinal Chemistry
Title: Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design
Volume: 12 Issue: 1
Author(s): Lidia Moreira Lima and Eliezer J. Barreiro
Affiliation:
Keywords: lead compound, isosterism, antagonist, pharmacodynamic, pharmacokinetic, hplc, prostaglandin-h synthase-2 (pghs-
Abstract: This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds.
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Cite this article as:
Lima Moreira Lidia and Barreiro J. Eliezer, Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design, Current Medicinal Chemistry 2005; 12 (1) . https://dx.doi.org/10.2174/0929867053363540
DOI https://dx.doi.org/10.2174/0929867053363540 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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