Abstract
Influenza is a disease that deeply affects millions of people every year. There has not been any drug effective against all strains. Neuraminidase (NA) is the major surface glycoprotein of the influenza virus, which possesses critical enzymatic activity and has been considered as a suitable target for designing agents against influenza viruses. Here we review the structure and functions of this enzyme and touch upon the structureactivity relationship (SAR) of existing influenza neuraminidase inhibitors (NAIs).
Keywords: Influenza virus, Neuraminidase, Structure, Functions, Neuraminidase inhibitors, Structure-activity relationship
Current Medicinal Chemistry
Title: Structure and Functions of Influenza Virus Neuraminidase
Volume: 14 Issue: 1
Author(s): Jianzhi Gong, Wenfang Xu and Jie Zhang
Affiliation:
Keywords: Influenza virus, Neuraminidase, Structure, Functions, Neuraminidase inhibitors, Structure-activity relationship
Abstract: Influenza is a disease that deeply affects millions of people every year. There has not been any drug effective against all strains. Neuraminidase (NA) is the major surface glycoprotein of the influenza virus, which possesses critical enzymatic activity and has been considered as a suitable target for designing agents against influenza viruses. Here we review the structure and functions of this enzyme and touch upon the structureactivity relationship (SAR) of existing influenza neuraminidase inhibitors (NAIs).
Export Options
About this article
Cite this article as:
Gong Jianzhi, Xu Wenfang and Zhang Jie, Structure and Functions of Influenza Virus Neuraminidase, Current Medicinal Chemistry 2007; 14 (1) . https://dx.doi.org/10.2174/092986707779313444
DOI https://dx.doi.org/10.2174/092986707779313444 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Multi-Shift Single-Vehicle Routing Problem Under Fuzzy Uncertainty
During the COVID-19 Pandemic
Journal of Fuzzy Logic and Modeling in Engineering Short Approach to Pyrrolopyrazino-, Pyrrolodiazepino-Isoindoles and their Benzo Analogues via the IMDAF Reaction
Current Organic Synthesis Design and Synthesis of 3-Arylisoxazoline-5-Carboxamide and 3-Arylisoxazoline-5-Acetamide Libraries as Potential Factor Xa Inhibitors
Letters in Drug Design & Discovery An Updated Review on SARS-CoV-2 Main Proteinase (M<sup>Pro</sup>): Protein Structure and Small-Molecule Inhibitors
Current Topics in Medicinal Chemistry Medicinal Properties of Mangiferin, Structural Features, Derivative Synthesis, Pharmacokinetics and Biological Activities
Mini-Reviews in Medicinal Chemistry Anti-Malarial
Current Bioactive Compounds SAR, QSAR and Docking of Anticancer Flavonoids and Variants: A Review
Current Topics in Medicinal Chemistry Passive Immunization as Tool to Identify Protective HIV-1 Env Epitopes
Current HIV Research Emerging Antimicrobial Applications of Nitric Oxide (NO) and NO-Releasing Materials
Anti-Infective Agents in Medicinal Chemistry Predicting Protein Structural Class for Low-Similarity Sequences via Novel Evolutionary Modes of PseAAC and Recursive Feature Elimination
Letters in Organic Chemistry Development, Recent Achievements and Current Directions of Research into GABA Uptake Inhibitors
Current Medicinal Chemistry Coronavirus (COVID-19) Outbreak: A Test of Viral Muscle Versus the Human Tussle
Applied Clinical Research, Clinical Trials and Regulatory Affairs Can Mandated BCG Vaccine Promote herd Immunity against Novel Coronavirus? A Potential Solution at Hand to Tackle Covid-19 Pandemic
Current Immunology Reviews (Discontinued) Revisiting Non-Cancer Drugs for Cancer Therapy
Current Topics in Medicinal Chemistry New Bicyclic Amines: Synthesis and SARs of their Action Against the Causative Organisms of Malaria and Sleeping Sickness
Current Medicinal Chemistry Discrimination of Active and Weakly Active Human BACE1 Inhibitors Using Self-Organizing Map and Support Vector Machine
Combinatorial Chemistry & High Throughput Screening Synthesis of Purine Derivatives as Scaffolds for a Diversity of Biological Activities
Current Organic Chemistry Clinical Pharmacology of Systemic Analgesics in Neonates
Current Drug Therapy Meet Our Editorial Board Member
Reviews on Recent Clinical Trials Gene Therapy in In Vivo Isolated Perfusion Models
Current Gene Therapy