Neuroendocrine tumours (NETs) represent a range of neoplasms that may arise from any
(neuro)endocrine cell situated in any part of the human body. As any other rare diseases, NETs face
several difficulties in relation to research. This review will describe some of the main challenges and
proposed solutions faced by researchers with expertise in rare malignancies.
Some of the most common challenges in clinical and translational research are enumerated in this review,
covering aspects from clinical, translational and basic research. NETs being a heterogeneous
group of diseases and a limited sample size of clinical and translational research projects are the main
Challenges with NETs lay over the disparities between healthcare models to tackle rare diseases. NETs
add an extra layer of complexity due to a numerous group of different entities.
Prospective real-world data trials are an opportunity for rare cancers with the revolution of electronic
health technologies. This review explores potential solutions to these challenges that could be useful
not only to the NET community but also to other rare tumours researchers.