A Brief Literature and Review of Patents on Thiazole Related Derivatives

Author(s): Diksha Sharma , Kushal K. Bansal , Archana Sharma , Meenakshi Pathak , Prabodh C. Sharma* .

Journal Name: Current Bioactive Compounds

Volume 15 , Issue 3 , 2019

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Graphical Abstract:


Abstract:

Background: Thiazole is widely investigated bioactive scaffold and dynamic tool in medicinal chemistry research. Significance of thiazole compounds are well documented as thiazole is an obligatory structure of number of currently available therapeutics. In spite of that, thiazole derivatives are endowed with myriad biological activities, such as antiviral, anticancer, antibacterial, antifungal, antimalarial, antiparkinsonian, anti-inflammatory activities and many more.

Methods: In recent past, different approaches have been introduced for synthesis of thiazole and related compounds. Intrinsic molecular interaction between newly synthesized thiazole compounds and plethora of drug targets/enzymes has rendered discovery of new drug molecules with advances in modes of action. A renewed interest in therapeutic use of thiazole derivatives has been seen among the prospective researchers as exemplified by influx of huge scientific articles and patents. Some important patents of anti-infective and anticancer interest have been addressed appropriately and are presented in tables.

Results: This review paper is a contemporary approach on therapeutic/applications of thiazole derivatives by summarizing important patents filed from 2000-2017. The main focus of these patents is on anti-infective and anticancer potential of thiazole based compounds.

Conclusion: These approaches may provide valuable information for the further design of more active biological agents through various modifications and derivatizations.

Keywords: Thiazole, patents, biological activities, antifungal, antidiuretic, leinamycin.

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VOLUME: 15
ISSUE: 3
Year: 2019
Page: [304 - 315]
Pages: 12
DOI: 10.2174/1573407214666180827094725
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