Oligosaccharide-based chiral stationary phases are frequently used for enantioselective
separations by different chromatographic techniques, namely gas chromatography,
high performance liquid chromatography, supercritical fluid chromatography or capillary
electrochromatography. Their multimodal application potential (they are compatible with
both polar and/or non-polar mobile phases) makes them suitable chiral selector candidates
for separation of a wide variety of structurally diverse compounds. In this paper, separation
systems utilizing cyclodextrin- or cyclofructan-based chiral stationary phases in analyses of
pharmacologically active compounds are summarized. The review covers the period from
2000 to 2015. This review article can be helpful to analysts searching for an appropriate
method for the separation/determination of pharmaceuticals of their interest.
Keywords: Cyclodextrin, cyclofructan, pharmaceuticals, drugs, enantioseparation, enantioselectivity, chromatography.
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