The Mechanism of the Beneficial Effect of Botulinum Toxin Type a Used in the Treatment of Temporomandibular Joints Dysfunction

Author(s): Pihut Malgorzata, Ceranowicz Piotr, Kijak Edward.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 17 , Issue 5 , 2017


In the course of temporomandibular joint, dysfunctions very often occur to the excessive increase in tension of masticatory muscles, so the main aim of the treatment is reduction of this hypertension of muscles. For this reason, we use botulinum toxin type A, which is produced by Grampositive Clostridium bacteria. There are six serotypes of the toxin: A, B, C, D, E, F, and G. The botulinum toxin type A was first isolated in 1920s. Today, botulinum toxin type A is used increasingly more often as an efficient and patient-friendly therapy in neurology, ophthalmology, neurology, urology and laryngology. The aim of the article was to review the literature and description of the current knowledge concerned with mechanism of action of botulinum toxin type A, clinical applications and metabolic determinants of muscle contraction and the beneficial effect of this drug on the state of muscle tension.

Keywords: Botulinum toxin, heavy chain of botulinum toxin, light chain, muscular relaxation, neurotransmitter, temporomandibular join dysfunction.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2017
Page: [445 - 450]
Pages: 6
DOI: 10.2174/1389557516666160506151610
Price: $58

Article Metrics

PDF: 22