Abstract
From their discovery half a century ago and the subsequent appreciation of their clinical utility, liposomes currently hold a recognized position in the mainstream of drug delivery systems. Conventional techniques for liposome preparation and size reduction are simple to implement and do not require sophisticated equipment. However, most of them are not easy to scale-up for industrial liposome production. With several liposomal formulations already on the market, and more in final clinical trials, the industrial scale production of liposomes has become reality, and so the range of liposome preparation methods has been extended by a number of techniques which are increasingly attractive, such as microfluidic hydrodynamic focusing, supercritical fluid processing, freeze-drying and spray-drying. Some of these new techniques generally represent advancements of the conventional methods allowing for scale-up, better reproducibility and process control. This review summarizes patents in the last decade offering new techniques for production of liposomes as related to their application in drug delivery.
Keywords: Drug delivery, liposome, vesicle, lipid, microfluidic, supercritical fluid, nanoparticle.
Recent Patents on Nanotechnology
Title:Recent Progress in Liposome Production, Relevance to Drug Delivery and Nanomedicine
Volume: 9 Issue: 2
Author(s): Rumiana Koynova and Boris Tenchov
Affiliation:
Keywords: Drug delivery, liposome, vesicle, lipid, microfluidic, supercritical fluid, nanoparticle.
Abstract: From their discovery half a century ago and the subsequent appreciation of their clinical utility, liposomes currently hold a recognized position in the mainstream of drug delivery systems. Conventional techniques for liposome preparation and size reduction are simple to implement and do not require sophisticated equipment. However, most of them are not easy to scale-up for industrial liposome production. With several liposomal formulations already on the market, and more in final clinical trials, the industrial scale production of liposomes has become reality, and so the range of liposome preparation methods has been extended by a number of techniques which are increasingly attractive, such as microfluidic hydrodynamic focusing, supercritical fluid processing, freeze-drying and spray-drying. Some of these new techniques generally represent advancements of the conventional methods allowing for scale-up, better reproducibility and process control. This review summarizes patents in the last decade offering new techniques for production of liposomes as related to their application in drug delivery.
Export Options
About this article
Cite this article as:
Koynova Rumiana and Tenchov Boris, Recent Progress in Liposome Production, Relevance to Drug Delivery and Nanomedicine, Recent Patents on Nanotechnology 2015; 9 (2) . https://dx.doi.org/10.2174/187221050902150819151721
DOI https://dx.doi.org/10.2174/187221050902150819151721 |
Print ISSN 1872-2105 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4020 |
Call for Papers in Thematic Issues
Advances in Vanadium and Titanium Resources for High-performance Materials via Nanostructuring and Nanoengineering (updated BMS-NANOTEC-2023-HT-31)
Vanadium and titanium-based materials are ideal candidates for structural and functional materials in aerospace, biomedical engineering, optics, catalysis, energy storage and conversion etc. Vanadium/titanium-based alloys, compounds and materials have a large family with different chemical compositions, dimensions, structures/morphologies, and chemical/physical/mechanical properties, which provides huge opportunities for the development of emerging ...read more
Green Nanotechnology and Nanomaterials for a Sustainable Environment
Green nanotechnology (GN) might wind up being the most efficient platform for achieving the goals of the 2030 Agenda. The goal of GN is to create goods and procedures that are secure, energy-efficient, waste-free, and emit fewer greenhouse gases. Such goods and procedures use renewable resources, and/or their environmental impact ...read more
NANOSTRUCTURED NEUROMORPHIC DEVICES: TOWARDS IN MATERIA COMPUTING
The efforts pursued in the last decade to build up brain-inspired systems with electronic hardware solutions to solve complex data processing tasks, have leaded to the development of a new generation of devices, as memristor crossbar arrays, and their different applications became more and more reliable. One of the basic ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Targeted Tumor Immunotherapy: Are Vaccines the Future of Cancer Treatment?
Current Drug Therapy Pharmacovigilance Assessment of Cardiac Implications of Nicotine Replacement Therapy Among Smokers
Current Drug Safety SUBJECT INDEX TO VOLUME 1
Current Genomics Anticancer Immunotherapy in Combination with Proapoptotic Therapy
Current Cancer Drug Targets Systemic Delivery and Quantification of Unformulated Interfering RNAs In Vivo
Current Topics in Medicinal Chemistry Brachial Plexopathy as a Complication of Radiotherapy: A Systematic Review
Current Cancer Therapy Reviews The Synthetic Oleanane Triterpenoid HIMOXOL Induces Autophagy in Breast Cancer Cells via ERK1/2 MAPK Pathway and Beclin-1 Up-regulation
Anti-Cancer Agents in Medicinal Chemistry Polo-Like Kinases Inhibitors
Current Medicinal Chemistry Somatostatin and its Analogs
Current Drug Targets Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia
Current Psychiatry Reviews Current Nanotechnological Approaches for an Effective Delivery of Bioactive Drug Molecules to Overcome Drug Resistance Tuberculosis
Current Pharmaceutical Design Magnetic Resonance Nano-Theranostics for Glioblastoma Multiforme
Current Pharmaceutical Design The Cellular Uptake and Apoptotic Efficiency of Colchicine is Correlated with Downregulation of MMP-9 mRNA Expression in SW480 Colon Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry The Biological Effects of Diagnostic Cardiac Imaging
Current Pharmaceutical Design Roles of Medicinal Plants and Constituents in Gynecological Cancer Therapy: Current Literature and Future Directions
Current Topics in Medicinal Chemistry Advances in the Discovery of Anthraquinone-Based Anticancer Agents
Recent Patents on Anti-Cancer Drug Discovery Monoclonal Antobodies: Application in Radiopharmacy
Current Radiopharmaceuticals Pharmacogenetics of Phase I and Phase II Drug Metabolism
Current Pharmaceutical Design Recent Progress in Stimuli-Responsive Intelligent Nano Scale Drug Delivery Systems: A Special Focus Towards pH-Sensitive Systems
Current Drug Targets Salidroside - Can it be a Multifunctional Drug?
Current Drug Metabolism