Different 6-Aryl-Fulvenes Exert Anti-proliferative effects on Cancer Cells
Maria Stefania Sinicropi,
Fulvenes represent a class of molecules very interesting under a chemical point of view because are
easily accessible starting materials and are still poorly characterized for their biological activities, with the
exception of acylfulvene and irofulvenes which have been reported to exert cytotoxic properties. Here, we
describe the synthesis and characterization of several aryl-fulvenes together with their effects on cancer cell
growth by MTT method. The cytotoxic potential was investigated on a panel of tumor cell lines such as breast
MCF7 and SkBr3, endometrial Ishikawa, prostate LnCaP and lung A549, in comparison with the cis-diamminedichloroplatinum(II)
(cisplatin) which is largely used for the treatment of different types of cancer. The evaluation of the cytotoxic activity of these
compounds indicated that they are able to inhibit the proliferation of the aforementioned cancer cell types. In particular, the compound 4
exhibited the most powerful antiproliferative activity on all tumor cells evaluated with higher inhibitory effects respect to cisplatin and
without altering the proliferation of human mammary MCF-10A epithelial cells.
Keywords: Antiproliferative activity, A549, Fulvenes, Ishikawa, LnCaP, MCF-10A, MCF7, SkBr3.
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