This study describes the synthesis of novel 4-nitro-2-substitutedimidazole derivatives via a transposition reaction
of nitro group. Conversion of 5-nitro-2-phenylethanol (styryl) imidazole derivatives into the corresponding 4-
nitroisomers was achieved in good yields in nitrobenzene using a catalytic amount of methyl iodide. Spectroscopic study
and single crystal X-ray structures are reported for five compounds to understand the conformational structures of these
Keywords: Transposition reaction, 4-nitroimidazole, 5-nitroimidazole, crystal structure.
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