Synthesis, Characterization and Biological Evaluation Against Influenza Virus Agonists of (N'E,N'"E)-2,2'-[[1,1'-Biphenyl]-4,4'-dihylbis(oxy)]bis (N'-arylmethyleneacetohydrazides)

Title:Synthesis, Characterization and Biological Evaluation Against Influenza Virus Agonists of (N'E,N'"E)-2,2'-[[1,1'-Biphenyl]-4,4'-dihylbis(oxy)]bis (N'-arylmethyleneacetohydrazides)

Volume: 11 Issue: 3

Author(s): El Sayed H. El Ashry, Zia Ud Din, Zahid H. Soomro, Wajid Rahman, Muhammad Raza Shah, Yeldez El Kilany, Lieve Naesens and Ahmed T.A. Boraei

Affiliation:

Keywords: Aryloxyacetohydrazides, hydrazones, bisphenols, influenza virus.

Abstract: N',N"'-[2,2'-[[1,1'-Biphenyl]-4,4'-diylbis(oxy)]bis(acetyl)]di(benzohydrazide) 3 was prepared by reaction of 2,2'-[1,1'-biphenyl]-4,4'-diylbis(oxy)]bisacetohydrazide 2 with benzoyl chloride. A new series of the arylidene 4-15 was prepared by heating 2 with the following aldehydes: 4-flourobenzaldehyde, p-tolualdehyde, 2-hydroxy-3- methoxybenzaldehyde, 2-chlorobenzaldehyde, isonicotinaldehyde (4-pyridine carboxaldehyde), benzaldehyde, 4- chlorobenzaldehyde, picolinaldehyde (2-pyridine carboxaldehyde), 4-methoxybenzaldehyde (4-anisaldehyde), 3- bromobenzaldehyde, 2,4,6-trimethoxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde (vaniline). The compounds were evaluated against influenza virus. Two compounds showed moderate activity which means that with more derivatization, better activity could be expected.

Cite this article as:

Ashry Sayed H. El El, Din Ud Zia, Soomro H. Zahid, Rahman Wajid, Shah Raza Muhammad, Kilany El Yeldez, Naesens Lieve and Boraei T.A. Ahmed, Synthesis, Characterization and Biological Evaluation Against Influenza Virus Agonists of (N'E,N'"E)-2,2'-[[1,1'-Biphenyl]-4,4'-dihylbis(oxy)]bis (N'-arylmethyleneacetohydrazides), Letters in Organic Chemistry 2014; 11 (3) . https://dx.doi.org/10.2174/1570178610666131118222358