Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy

Author(s): P. Russo , A. Del Bufalo , A. Cesario .

Journal Name: Current Medicinal Chemistry

Volume 19 , Issue 31 , 2012

Abstract:

Flavonoids, secondary metabolites ubiquitously produced in the plant kingdom, are low molecular weight polyphenolic molecules. They are characterized by variable chemical structures and show a vast array of biological activities (i.e... antiviral, antiinflammatory, antitumor, antimicrobial, estrogenic, antiestrogenic, antioxidant, mutagenic and antimutagenic) targeting different pathways. Some of these compounds such as Genistein, Daidzein or its synthetic derivative Phenoxodiol as well as Luteolin and Quercetin are able to inhibit DNA topoisomerases. This review discusses that Flavonoids targeting DNA topoisomerases may lead to novel drug development with anticancer potential.

Keywords: Cell death, clinical trials, DNA topoisomerases, DNA topoisomerases poisoning, drug discovery and development, flavonoids, phenoxodiol, systems Biology, therapeutic agents, Luteolin

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Article Details

VOLUME: 19
ISSUE: 31
Year: 2012
Page: [5287 - 5293]
Pages: 7
DOI: 10.2174/092986712803833272
Price: $58

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