Abstract
In this study, the novel germatrane compound, 3-(2, 8, 9-trioxa-5-aza-1- germatricyclo [3.3.3.0] undecane-1- yl)-3-(4-hydroxy-3- methoxyphenyl)-propionic acid (1), has been synthesized and its activities against cervical tumor U14 were evaluated in vitro and in vivo. The results have demonstrated that the compound posed significant inhibition on U14 tumor with IC50 values of 48.57 mg/L in cell-based assay and tumor inhibitory rates of 38.50 %, 47.17 % and 64.02 % (from low dose to high dose) in animal experiment.
Keywords: Germanium, ferulic acid, synthesis, trichlorogermane, germatrane, 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3. 3. 3.0] undecane-1-yl)-3-(4-hydroxy-3- methoxyphenyl)-propionic acid, U14 tumor, antitumor activity, inhibitory rate, germatrane compound
Medicinal Chemistry
Title:Synthesis of 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3.3.3.0] Undecane-1- yl)-3-(4-hydroxyl-3-methoxyphenyl)-propionic Acid and its Inhibitory Effect on the Cervical Tumor U14 in vitro and in vivo
Volume: 8 Issue: 4
Author(s): Lianbao Ye, Xiaomin Ou, Xuedong Peng and Yan Luo
Affiliation:
Keywords: Germanium, ferulic acid, synthesis, trichlorogermane, germatrane, 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3. 3. 3.0] undecane-1-yl)-3-(4-hydroxy-3- methoxyphenyl)-propionic acid, U14 tumor, antitumor activity, inhibitory rate, germatrane compound
Abstract: In this study, the novel germatrane compound, 3-(2, 8, 9-trioxa-5-aza-1- germatricyclo [3.3.3.0] undecane-1- yl)-3-(4-hydroxy-3- methoxyphenyl)-propionic acid (1), has been synthesized and its activities against cervical tumor U14 were evaluated in vitro and in vivo. The results have demonstrated that the compound posed significant inhibition on U14 tumor with IC50 values of 48.57 mg/L in cell-based assay and tumor inhibitory rates of 38.50 %, 47.17 % and 64.02 % (from low dose to high dose) in animal experiment.
Export Options
About this article
Cite this article as:
Ye Lianbao, Ou Xiaomin, Peng Xuedong and Luo Yan, Synthesis of 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3.3.3.0] Undecane-1- yl)-3-(4-hydroxyl-3-methoxyphenyl)-propionic Acid and its Inhibitory Effect on the Cervical Tumor U14 in vitro and in vivo, Medicinal Chemistry 2012; 8 (4) . https://dx.doi.org/10.2174/157340612801216157
DOI https://dx.doi.org/10.2174/157340612801216157 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Myogenic Tone as a Therapeutic Target for Ischemic Stroke
Current Vascular Pharmacology Adenosine and ATP Receptors in the Brain
Current Topics in Medicinal Chemistry Antihemostatic Strategies of Blood-Feeding Arthropods
Current Drug Targets - Cardiovascular & Hematological Disorders Nailfold Capillaroscopy – Its Role in Diagnosis and Differential Diagnosis of Microvascular Damage in Systemic Sclerosis
Current Rheumatology Reviews Cerebroprotective Functions of HO-2
Current Pharmaceutical Design Use of Medication in Coronary Imaging by CT
Current Medical Imaging Air Pollution Exposure and Blood Pressure: An Updated Review of the Literature
Current Pharmaceutical Design Endothelial Function and Pathogenesis of Endothelial Dysfunction
Current Immunology Reviews (Discontinued) Topical Bimatoprost Insert for Primary Open-Angle Glaucoma and Ocular Hypertension Treatment - A Phase II Controlled Study
Current Drug Delivery Investigation of Cytotoxic Effects of Oxymetazoline on Lungs in a Rat Model of Rhinitis Medicamentosa
Current Molecular Pharmacology Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice
Current Medicinal Chemistry Exploring the use of Estrogen & Progesterone Replacement Therapy in Subarachnoid Hemorrhage
Current Drug Safety Endothelial Function: A Surrogate Endpoint in Cardiovascular Studies?
Current Pharmaceutical Design Adiponectin and its Role in Cardiovascular Diseases
Cardiovascular & Hematological Disorders-Drug Targets Medication-Induced Acute Abdominal Pain: Evaluation with CT Imaging
Current Medical Imaging Towards a Better Understanding of Cardiac and Vascular Disease in Patients with Chronic Kidney Disease
Current Cardiology Reviews Pathophysiology of Blood-Brain Barrier in Brain Injury in Cold and Hot Environments: Novel Drug Targets for Neuroprotection
CNS & Neurological Disorders - Drug Targets Post-locoregional Therapy MRI Evaluation of Malignant Liver Lesions
Current Cancer Therapy Reviews Current Evidence and Future Perspectives on Anti-platelet and Statin Pharmacotherapy for Patients with Symptomatic Peripheral Arterial Disease
Current Vascular Pharmacology Insulin Resistance is Associated with Subclinical Vascular Injury in Patients with a Kidney Disease
Current Cardiology Reviews