Abstract
We report the use of estrone (E1)-based compounds in the search for inhibitors of 17β-hydroxysteroid dehydrogenase, in particular, type 3 (17β-HSD3). Results suggest that the compounds are good inhibitors of 17β-HSD3 and a number were found to be equipotent to the standard inhibitors used within the current study.
Keywords: 17β-Hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme, Steroid-based compound, Prostate cancer, Estrone, Potential Inhibitors, Estrone (E1)-based compounds, Type 3 (17bHSD3), Standard inhibitors, Biochemical target, Androgen-dependent cancer, Breast cancer, Ester-based derivatives, Non-radioactive steroids, Perkin-Elmer Fourier Transform Paragon, PET polyester, 17b-Hydroxysteroid dehydrogenase, Inhibitory activity, Cycloalkyl based compounds
Letters in Drug Design & Discovery
Title: Estrone (E1) Based Esters as Potential Inhibitors of Type 3 17β- hydroxysteroid Dehydrogenase (17β-HSD3) in the Treatment of Hormone-Dependent Prostate Cancer
Volume: 7 Issue: 9
Author(s): Moniola S. Olusanjo and Sabbir Ahmed
Affiliation:
Keywords: 17β-Hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme, Steroid-based compound, Prostate cancer, Estrone, Potential Inhibitors, Estrone (E1)-based compounds, Type 3 (17bHSD3), Standard inhibitors, Biochemical target, Androgen-dependent cancer, Breast cancer, Ester-based derivatives, Non-radioactive steroids, Perkin-Elmer Fourier Transform Paragon, PET polyester, 17b-Hydroxysteroid dehydrogenase, Inhibitory activity, Cycloalkyl based compounds
Abstract: We report the use of estrone (E1)-based compounds in the search for inhibitors of 17β-hydroxysteroid dehydrogenase, in particular, type 3 (17β-HSD3). Results suggest that the compounds are good inhibitors of 17β-HSD3 and a number were found to be equipotent to the standard inhibitors used within the current study.
Export Options
About this article
Cite this article as:
S. Olusanjo Moniola and Ahmed Sabbir, Estrone (E1) Based Esters as Potential Inhibitors of Type 3 17β- hydroxysteroid Dehydrogenase (17β-HSD3) in the Treatment of Hormone-Dependent Prostate Cancer, Letters in Drug Design & Discovery 2010; 7 (9) . https://dx.doi.org/10.2174/157018010792929496
DOI https://dx.doi.org/10.2174/157018010792929496 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
3,4,5-Trisubstituted-1,2,4-triazole Derivatives as Antiproliferative Agents: Synthesis, In vitro Evaluation and Molecular Modelling
Letters in Drug Design & Discovery Smart Polymer Based Delivery Systems for Peptides and Proteins
Recent Patents on Drug Delivery & Formulation Relevance of Pharmacokinetics and Bioavailability of Intranasal Corticosteroids in Allergic Rhinitis
Recent Patents on Inflammation & Allergy Drug Discovery Can We Predict the Sites of the Recurrence of Ovarian Cancer by F-18 FDG PET/CT Depending on CA-125 Level?
Current Medical Imaging Interrelationships Among Gut Microbiota and Host: Paradigms, Role in Neurodegenerative Diseases and Future Prospects
CNS & Neurological Disorders - Drug Targets Editorial Review of 2014
Current Radiopharmaceuticals Rac-1 as a New Therapeutic Target in Cerebro- and Cardio-Vascular Diseases
Current Drug Targets Radiolabeled GRPR Antagonists for Imaging of Disseminated Prostate Cancer - Influence of Labeling Chemistry on Targeting Properties
Current Medicinal Chemistry Targeting Mitochondria in Fighting Cancer
Current Pharmaceutical Design Bcl-2 Family Proteins Regulate Apoptosis and Epithelial to Mesenchymal Transition by Calcium Signals
Current Pharmaceutical Design The Quest for Surrogate Markers of Angiogenesis: A Paradigm for Translational Research in Tumor Angiogenesis and Anti- Angiogenesis Trials
Current Molecular Medicine Zebrafish As a Genetic Model in Pre-Clinical Drug Testing and Screening
Current Medicinal Chemistry Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines
Anti-Cancer Agents in Medicinal Chemistry Subject Index to Volume 10
Current Pharmaceutical Design Interactions of Curcumin and Its Derivatives with Nucleic Acids and their Implications
Mini-Reviews in Medicinal Chemistry The Potential Anti-Tumorigenic and Anti-Metastatic Side of the Proprotein Convertases Inhibitors
Recent Patents on Anti-Cancer Drug Discovery Recent Advancements in Nanotechnology for Oral Cancer: a Review
Current Drug Therapy The Synthetic Oleanane Triterpenoid HIMOXOL Induces Autophagy in Breast Cancer Cells via ERK1/2 MAPK Pathway and Beclin-1 Up-regulation
Anti-Cancer Agents in Medicinal Chemistry Transcranial Magnetic Stimulation to Understand the Pathophysiology and Treatment of Substance Use Disorders
Current Drug Abuse Reviews Positron Emitting Tracers in Pre-Clinical Drug Development
Current Radiopharmaceuticals