Abstract
Many therapeutic reagents for hepatitis B virus infection have established efficacy in goals such as alanine aminotransferase normalization, hepatitis B virus DNA suppression, HBeAg seroconversion, histological improvement, and reduce disease progression. However, it is not established that the efficacy of these reagents for the long-term survival and prevention of hepatocellular carcinoma although recent meta-analyses have also shown antiviral therapy to be efficacious. This article reviews the current status and innovative new options for antiviral therapy for hepatitis B and also discusses the various mechanisms of action for each drug, the results of clinical studies for each therapy, and the problems yet to be solved with respect to hepatitis B treatment.
Keywords: Hepatitis B virus, therapy, host cellular target, life cycle, interferon, nucleoside/nucleotide analog, adverse effects, drug resistance
Mini-Reviews in Medicinal Chemistry
Title: Current and Novel Therapies for Hepatitis B Virus Infection
Volume: 10 Issue: 1
Author(s): K. Sato and M. Mori
Affiliation:
Keywords: Hepatitis B virus, therapy, host cellular target, life cycle, interferon, nucleoside/nucleotide analog, adverse effects, drug resistance
Abstract: Many therapeutic reagents for hepatitis B virus infection have established efficacy in goals such as alanine aminotransferase normalization, hepatitis B virus DNA suppression, HBeAg seroconversion, histological improvement, and reduce disease progression. However, it is not established that the efficacy of these reagents for the long-term survival and prevention of hepatocellular carcinoma although recent meta-analyses have also shown antiviral therapy to be efficacious. This article reviews the current status and innovative new options for antiviral therapy for hepatitis B and also discusses the various mechanisms of action for each drug, the results of clinical studies for each therapy, and the problems yet to be solved with respect to hepatitis B treatment.
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Cite this article as:
Sato K. and Mori M., Current and Novel Therapies for Hepatitis B Virus Infection, Mini-Reviews in Medicinal Chemistry 2010; 10 (1) . https://dx.doi.org/10.2174/138955710791112613
DOI https://dx.doi.org/10.2174/138955710791112613 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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