Diphenylpentane Skeleton as a Multi-Template for Steroid Skeleton- Recognizing Receptors/Enzymes

Shinnosuke      Hosoda; Daisuke      Matsuda; Hiroshi      Tomoda; Yuichi      Hashimoto

Abstract

As an example of a multi-template approach, we focused on the 3,3-diphenylpentane (DPP) skeleton, which has been demonstrated to act as a steroid skeleton substitute. Various ligands for nuclear receptors (NRs), including vitamin D receptor (VDR), androgen receptor (AR) and farnesoid X receptor (FXR), and inhibitors of steroid metabolismrelated enzymes, including 5α-reductase and HMG-CoA reductase (HMGR), have been efficiently created by introducing various substituents onto the DPP skeleton.

Keywords: Multi-template, steroids, diphenylpentane skeleton, steroid skeleton substitute, nuclear receptor, vitamin D receptor, androgen receptor, farnesoid X receptor, 5α-reductase, HMG-CoA reductase