Abstract
The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.
Keywords: Proprotein convertases, prosegments, inhibitors, processing, maturation, substrates
Medicinal Chemistry
Title: Inhibitory Feature of the Proprotein Convertases Prosegments
Volume: 4 Issue: 2
Author(s): Abdel-Majid Khatib, Yannick Bontemps, Marion Lapierre, Geraldine Siegfried and Fabien Calvo
Affiliation:
Keywords: Proprotein convertases, prosegments, inhibitors, processing, maturation, substrates
Abstract: The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.
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Cite this article as:
Khatib Abdel-Majid, Bontemps Yannick, Lapierre Marion, Siegfried Geraldine and Calvo Fabien, Inhibitory Feature of the Proprotein Convertases Prosegments, Medicinal Chemistry 2008; 4 (2) . https://dx.doi.org/10.2174/157340608783789176
DOI https://dx.doi.org/10.2174/157340608783789176 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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