Abstract
(R)-Arundic acid 15 was prepared in a simple manner and with absolute optical purity via Cu and Fe mediated and Luches crotylation of 1 with bromides 6a,b. Co wasnt a good mediator for these crotylation reactions. The stereoselectivity for all crotylations were similar producing mainly 7b, c, besides a small amount of 7a.
Keywords: Alzheimer disease, arundic acid, (R)-2,3-cyclohexylideneglyceraldehyde, crotylation, propargyl alcohol, stereoselectivity, ozonolysis, enantiopurity
Letters in Organic Chemistry
Title: Crotylation of (R)-2,3-Cyclohexylideneglyceraldehyde: A Simple Strategy for the Synthesis of Enantiopure anti-Alzheimer (R)-Arundic Acid
Volume: 3 Issue: 12
Author(s): Dibakar Goswami and Angshuman Chattopadhyay
Affiliation:
Keywords: Alzheimer disease, arundic acid, (R)-2,3-cyclohexylideneglyceraldehyde, crotylation, propargyl alcohol, stereoselectivity, ozonolysis, enantiopurity
Abstract: (R)-Arundic acid 15 was prepared in a simple manner and with absolute optical purity via Cu and Fe mediated and Luches crotylation of 1 with bromides 6a,b. Co wasnt a good mediator for these crotylation reactions. The stereoselectivity for all crotylations were similar producing mainly 7b, c, besides a small amount of 7a.
Export Options
About this article
Cite this article as:
Goswami Dibakar and Chattopadhyay Angshuman, Crotylation of (R)-2,3-Cyclohexylideneglyceraldehyde: A Simple Strategy for the Synthesis of Enantiopure anti-Alzheimer (R)-Arundic Acid, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779468059
DOI https://dx.doi.org/10.2174/157017806779468059 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Ontologies of Drug Discovery and Design for Neurology, Cardiology and Oncology
Current Pharmaceutical Design CHF5074 Reduces Biomarkers of Neuroinflammation in Patients with Mild Cognitive Impairment: A 12-Week, Double-Blind, Placebo- Controlled Study
Current Alzheimer Research Recent Advances in Superparamagnetic Iron Oxide Nanoparticles for Cellular Imaging and Targeted Therapy Research
Current Pharmaceutical Design From Randomized Controlled Trials of Antidepressant Drugs to the Meta-Analytic Synthesis of Evidence: Methodological Aspects Lead to Discrepant Findings
Current Neuropharmacology Editorial (Thematic issue: “Alkaloids in Nature: Synthesis, Isolation and Pharmacological Applications” Part 1)
Current Topics in Medicinal Chemistry Neuroprotective Effects of Heat Shock Protein70
CNS & Neurological Disorders - Drug Targets Prepontine Chordoma Presenting with MRI Features of an Epidermoid Cyst: Case Presentation and a Mini-Review
Current Medical Imaging Candidate Susceptibility Genes in Alzheimers Disease Are at High Risk for Being Forgotten - They Dont Give Peace of Mind...
Current Drug Metabolism 5-HT7 Receptors
Current Drug Targets - CNS & Neurological Disorders Biomarkers of Oxidative Stress and the Relationship to Cigarette Smoking
Mini-Reviews in Organic Chemistry Restless Leg Syndrome Associated with Olanzapine: A Case Series
Current Drug Safety Kinases as Targets for Parkinson's Disease: From Genetics to Therapy
CNS & Neurological Disorders - Drug Targets Editorial: Herbal Medicine on High Impact Disease: The Current Progress and Application
Current Pharmaceutical Design Relevance of the Chronobiological and Non-chronobiological Actions of Melatonin for Enhancing Therapeutic Efficacy in Neurodegenerative Disorders
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Advanced Mass Spectrometry-Based Methods for the Analysis of Conformational Integrity of Biopharmaceutical Products
Current Pharmaceutical Biotechnology Mini-Mental Parkinson (MMP) as a Dementia Screening Test: Comparison with the Mini-Mental State Examination (MMSE)
Current Aging Science Microdose Lithium Treatment Stabilized Cognitive Impairment in Patients with Alzheimer’s Disease
Current Alzheimer Research Risk Analysis of Lurasidone in Patients with Schizophrenia and Bipolar Depression
CNS & Neurological Disorders - Drug Targets Variability in Reward Responsivity and Obesity: Evidence from Brain Imaging Studies
Current Drug Abuse Reviews Nociceptinergic System as Potential Target in Parkinson’s Disease
Mini-Reviews in Medicinal Chemistry