Abstract
Skin cancer is the most common malignancy. Its pathogenesis is a multi-step, cumulative process which allows for potential intervention along the length of its spectrum. Cancer chemoprevention is a very promising approach to obtaining this goal. Unfortunately, its widespread application in clinic has been hampered by several problems, including systemic side effects especially if the medication requires prolonged use. For this reason, possible alternative measures have been investigated and are of great interest. The application of phytochemicals and other natural compounds is an appealing approach in that they are generally nontoxic, less costly and widely available. Topical application (e.g., transdermal systems, painting) of chemopreventives also serves as an alternative to systemic administration, and may limit side effects without sacrificing clinical advantages. The purpose of this paper is to provide an extensive investigation of the literature regarding current chemopreventative practices. This paper focuses discussions on the topical application of phytochemicals, by representing recent studies and findings. Based on recognition amongst the literature, five compounds are represented which include resveratrol, green tea, perillyl alcohol, ginger and inositol hexaphosphate. More compounds are also named with brief introduction, and further study is discussed.
Keywords: Skin cancer, chemoprevention, phytochemicals, topical application
Current Cancer Therapy Reviews
Title: Topical Chemoprevention of Skin Cancers with Phytochemicals
Volume: 7 Issue: 3
Author(s): Lining Feng, Mary C. Zoccoli and Zhi Wang
Affiliation:
Keywords: Skin cancer, chemoprevention, phytochemicals, topical application
Abstract: Skin cancer is the most common malignancy. Its pathogenesis is a multi-step, cumulative process which allows for potential intervention along the length of its spectrum. Cancer chemoprevention is a very promising approach to obtaining this goal. Unfortunately, its widespread application in clinic has been hampered by several problems, including systemic side effects especially if the medication requires prolonged use. For this reason, possible alternative measures have been investigated and are of great interest. The application of phytochemicals and other natural compounds is an appealing approach in that they are generally nontoxic, less costly and widely available. Topical application (e.g., transdermal systems, painting) of chemopreventives also serves as an alternative to systemic administration, and may limit side effects without sacrificing clinical advantages. The purpose of this paper is to provide an extensive investigation of the literature regarding current chemopreventative practices. This paper focuses discussions on the topical application of phytochemicals, by representing recent studies and findings. Based on recognition amongst the literature, five compounds are represented which include resveratrol, green tea, perillyl alcohol, ginger and inositol hexaphosphate. More compounds are also named with brief introduction, and further study is discussed.
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Cite this article as:
Feng Lining, C. Zoccoli Mary and Wang Zhi, Topical Chemoprevention of Skin Cancers with Phytochemicals, Current Cancer Therapy Reviews 2011; 7 (3) . https://dx.doi.org/10.2174/157339411796234924
DOI https://dx.doi.org/10.2174/157339411796234924 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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