Current Cancer Therapy Reviews

ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

Volume 18, Issue 4, 2022

This journal supports open access

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Editorial Board


cctr Editor-in-Chief cctr_ebm_chen-Yangchao_001 Chen Yangchao School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Shatin Hong Kong

He is a Principal Investigator at Cancer Biology & Experimental Therapeutics Theme, School of Biomedical Sciences, CUHK. He is also the Principal Investigator at Shenzhen Research Institute, CUHK at Shenzhen. He is actively involved in molecular biology of pancreatic cancer and liver cancer. He is also an active reviewer of multiple grant agencies and peer-reviewed journals.

yangchaochen@cuhk.edu.hk
Co-Editor cctr_ebm_mocelin-simone_001 Mocellin Simone Department of Experimental Medicine and Immunotherapy University of Padova Padova Italy

Dr. Simone Mocelin obtained Doctorate in Oncology and Surgical Oncology from the University of Padova Italy. Dr. Mocelin is presently serving as an Associate Professor of Surgery and Gastroenterology in the same University and he is also a Surgeon at the Surgical Oncology Unit. He has contributed more the 250 Publications having citation around 9110. He is a member of the editorial board of several international peer-review medical journals and is an editor of the Cochrane Colorectal Cancer Group.

mocellins@hotmail.com
Regional Editor Europe cctr_ebm_santini_001 Santini Daniele Delegato al Coordinamento Didattico per il Corso di Laurea in Medicina e Chirurgia University Campus Bio-Medico Rome Italy

Prof. Daniele Santini obtained the PhD in Immunophysiology at the University of Palermo. He has been Associate Professor of General Pathology at the Campus Bio-Medical University and Head of the Oncologic Day Hospital's Simple Operational Unit (UOS) at the Politecnico Universitario Campus Bio-Medico in Rome. As Co-Head of the Laboratory of Transnational Oncology, he leads numerous preclinical and translational studies with the collaboration of his staff. He is a member of many scientific societies (AIOM, ISO, ESMO GOIM, etc). He is an effective member of the Editorial Board and a reviewer of papers of some international scientific journals. He is author of over 300 publications in national and international scientific journals featuring impact factors.

d.santini@unicampus.it
Frontiers Section Editor topharmj_ebm_schwartz_001 Schwartz Joel College of Dentistry University of Illinois Chicago IL USA

He obtained training for Oral Maxillofacial Pathology from Harvard School of Medicine and Dana –Farber Cancer Center and is presently the Director of Oral Maxillofacial Pathology Research at the College of Dentistry, University of Illinois. His first studies focused on viral carcinogenesis and immune regulation. In 1970s, he reported that early detection and prevention of oral cancer can be influenced by diet and molecular pathways that regulate epithelial cell growth and differentiation. These associations are examined through animal models to study mucosa responses to carcinogens and immunology and epithelial biology of normal and tumorigenic cells, cell lines.

joschwar@uic.edu Craniofacial Pathobiology
Section Editors topharmj_se_Ryu-sa_001 Clinical Oncology Ryu Dong Hee Department of Surgery Chungbuk National Univ. Hospital Cheongju South Korea

Dr. Dong Hee Ryu did Doctor of Philosophy in Medicine from the Chungbuk National University Cheongju, Korea in 2011. He did Doctor of Medicine and Master of Medicine both from the same university in 1994 and 1998, respectively. He did Resident Training in Surgery in 1999 from Chungbuk National University Hospital. From 1999-2002, he served in the Military as an Army surgeon. From 2002-2005, he was Chief in the Department of Surgery at the Cheongju St. Mary`s Hospital. Dr. Ryu is a member of a number of societies, such as The Korean Surgical Society, The Korean Association of HBP Surgery, Asia Pacific HPB Association Member, and the European Association for Transluminal Surgery(EATS). Currently, Dr. Ryu is serving as a Professor at the Chungbuk National University College of Medicine, Cheongju, Korea since 2017.

topharmj_se_Motadi_001 Apoptosis Aymond Motadi Lesetja Raymond Department of Biochemistry University of the Witwatersrand Johannesburg South Africa

Prof. Lesetja Raymond Motadi has B.Med Sci, M.Med and PhD in medical biochemistry. An academic cancer researcher with over 17 years’ postdoctoral experience encompassing undergraduate and postgraduate teaching and supervision with extensive research experience. He has a record of publications in high impact international journals. His research interest is in cancer biology, genetics and drug discovery. Current National Research Foundation (NRF) rated him with a C2 rating in 2021. He has a research background in a highly specialized area of molecular oncology and apoptosis with international recognition, which are reflected through his review articles in the international journals of high standard for e.g. Cell death and Disease; and through his keynote lectures at the international conferences.

Editorial Board Members cctr_ebm_Schlom-j-sa_001 Schlom Jeffrey Laboratory of Tumor Immunology and Biology NIH Clinical Center Bethesda MD USA schlomj@mail.nih.gov js141c@nih.gov cctr_ebm_cctr-Yang_001 Yang Feng School of pharmacy Guangxi normal University Guilin China

Feng Yang is a Principal Investigator at the School of pharmacy, Guangxi Normal University. Feng Yang is also the Principal Investigator at State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources. Feng Yang has been interested in research on protein oriented anti-cancer drugs. Feng Yang is also an active reviewer of multiple grant agencies and peer-reviewed journals.

cctr_ebm_srivastava-sk-ah_001 Srivastava Sanjay K. Department of Biomedical Sciences Texas Tech University Health Sciences Center Abilene TX USA

Dr. Sanjay K. Srivastava is currently a Distinguished Professor and Chair of Department of Immunotherapeutics and Biotechnology specializing in Cancer Biology, Chemoprevention and Therapeutics. He is also the Associate Dean for Sciences. Previously, he was a Professor in the Department of Biomedical Sciences. Prior to his arrival at TTUHSC, Dr. Srivastava served as an Assistant Professor in the Department of Pharmacology, University of Pittsburgh School of Medicine and was a full member of the University of Pittsburgh Cancer Institute. He did his post-doc from the University of Texas Medical Branch at Galveston, Texas. Dr. Srivastava’s research is focused on melanoma, brain cancer, breast cancer, pancreatic cancer, and ovarian cancer and is funded by grants from the National Cancer Institute, NIH. He has authored around 150 research papers and is the Editor of three books. Dr. Srivastava is on the editorial board of several journals and is the member of societies including American Association for Cancer Research, Society of Toxicology and AAPS. He also serves in the grant review panels of National Institute of Health (NIH), Department of Defense and Susan G. Komen Breast Cancer Foundation. His research work has been featured by news agencies including BBC, MSNBC, CBS, ABC, Science News etc.

sanjay.srivastava@ttuhsc.edu
cctr_ebm_li-jl-ah_001 Li Ji L. Orcid Department of Cancer Immunology University of Plymouth Plymouth UK 0000-0001-6200-1007 http://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=0CDIQFjAA&url=http%3A%2F%2Fscholar.google.co.uk%2Fcitations%3Fuser%3DUypFDoQAAAAJ%26hl%3Den&ei=MXasUr-ECJOI7AbupoCIAQ&usg=AFQjCNEPNdwOnVAeYqcem3XmGl81Uw_z1Q&sig2=J5sTVxkLPbVkkzrF2V0eiw&bvm=bv.57967247,d.ZGU https://www.researchgate.net/profile/Ji-Liang_Li

Ji-Liang Li is a full professor and chair in Cancer Immunology in Plymouth University Faculty of Medicine & Dentistry (PUFoMD), UK. He studied Medicine and had his postgraduate training with Master of Medicine from Sun Yat-Sen University in 1986. He received his PhD from London University London School of Hygiene and Tropical Medicine in 1997 and experienced as Postdoctoral Research Associate in the Department of Biochemistry at the University of Oxford from 1996-1999, Research Fellow at Imperial Cancer Research Fund from 1999-2002, Tenured Staff Scientist/Deputy Lab Head in Cancer Research UK from 2002 to 2007, and then Tenured Scientist/Deputy Lab Head in Weatherall Institute of Molecular Medicine at the University of Oxford from 2007-2015 prior to take the chair position at PUFoMD. Prof Li has published more than 80 peer-reviewed papers with an H- factor of 47. He serves as an editor/editorial board member for a dozen of international journals. His main fields of interests are within tumour microenvironment and its role in tumour invasion and metastasis, target and optimal therapies, and their translational medicine.

ji-liang.li@plymouth.ac.uk
cctr_ebm_savaskan-n-ah_001 Savaskan Nicolai Orcid Department of Neurosurgery University Hospital Erlangen Erlangen Germany 0000-0003-1348-094X https://www.researchgate.net/profile/Nicolai_Savaskan http://scholar.google.ch/citations?user=kLv_2c4AAAAJ&hl=en http://apps.webofknowledge.com/CitationReport.do?product=WOS&search_mode=CitationReport&SID=P1Nrk4GYERNys8q6Ub8&page=1&cr_pqid=4&viewType=summary&colName=WOS

Trained as a developmental neurobiologist, Nicolai Savaskan worked on axon guidance molecules and the PRG family before entering the cancer research field. Trained at the NKI and ETH Zurich, Nic is working on glutamate signalling in brain tumours and angiogenesis. Recently, Nic expanded his research on clinical brain tumour imaging including intraoperative fluorescence and MRi imaging leading to DiVA and vDiVA inventions. Major findings are heterogenic tumour zones in gliomas.

savaskan@gmx.net
cctr_ebm_robin-nr_001 Robin Nina R. Department of Pathological Anatomy and Cytology University of Auvergne Clermont-Ferrand France 55627369500

Dr. Nina Radosevic-Robin is presently a Senior Scientist (surgical & molecular pathologist / cell biologist) at INSERM U1240, Team 2, Biomarker Group University Clermont Auvergne, Department of Pathology Centre Jean Perrin, Clermont-Ferrand, France. Since 2013, she is also a research instructor (Instruction in research methods, supervision and conception of experiments, scientific and medical publications and presentations License) for Master, MD and PhD Programs at University of Auvergne.

nina.radosevic.robin@gmail.com
cctr_ebm_haq-r_001 Haq Rizwan Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA

Dr. Haq is a physician-scientist who specializes in metastatic melanoma. He received his MD and PhD at the University of Toronto and the Ontario Cancer Institute with various honors. His internal medicine training was in the Osler Housestaff Training Program at Johns Hopkins Hospital, followed by fellowship training in oncology at Dana-Farber/Harvard Cancer Care. At the completion of his clinical training, he was a post-doctoral fellow with Dr David E. Fisher (Massachusetts General Hospital). He has been a contributing author of numerous publications, including those published in Cancer Cell, Nature, Proceedings of the National Academy of Sciences USA. At Dana-Farber Cancer Institute, he is involved in developing the next generation of melanoma therapeutics and translating them to innovative investigator-initiated clinical trials. His clinical practice is dedicated to patients with melanoma.

Rizwan_Haq@dfci.harvard.edu
Marincola Francesco M. Department of Radiology Clinical Center, NIH Bethesda MD USA fmarincola@cc.nih.go fmarincola@gmail.com cctr_ebm_macri-a_001 Macrì Antonio Department of General Surgery University of Messina Messina Italy

Antonio Macrì is Associate Professor of Surgery at University of Messina and, in 2013, he became Full Professor of Surgery. Over the last 25 years, he has focused his scientific interests on the topics related to the abdominal oncology and, in the last 15 years, his principal field of research has become the treatment of peritoneal surface malignancies. He is responsible of the “Peritoneal Surface Malignancies and Sarcoma Program” of the University Hospital Medical School of Messina.

amacri@unime.it
cctr_ebm_zarogoulidis-p_001 Zarogoulidis Paul Pulmonary Department General Hospital Aristotle University of Thessaloniki Thessaloniki Greece

Dr. Paul Zarogoulidis, M.D, MS.c, Ph.D, is a pulmonary physician with expertise in interventional pulmonology and lung cancer treatment. He is a member of CABIP, ERS, ATS, EABIP. He is an associate editor in 3 journals and editor in 14 journals. He has 250 publications on pub med. He has written 3 chapters in 3 books. He is the president of `The Society for Diagnosis and Lung Cancer Treatment`. One of his main interests is the development of novel inhalational drugs and inhalational delivery systems. He is currently working in the Pulmonary Department-Oncology Unit, `’Theageneio’ Anticancer Hospital, Greece and 3 different private hospitals.

pzarog@hotmail.com
cctr_ebm_roesler_001 Roesler Rafael Department of Pharmacology Federal University of Rio Grande do Sul Porto Alegre Brazil

Rafael Roesler is the Deputy Director of Zenit Scientific and Technological Park of the Federal University of Rio Grande do Sul (UFRGS). He is Associate Professor in the Department of Pharmacology, Institute of Basic Health Sciences of UFRGS and Researcher level 1A of the National Council of Scientific and Technological Development (CNPq). He did PhD in Biochemistry, from UFRGS, 1999, and another Ph.D. as a visiting doctoral student from the University of California, Irvine, USA, 1997. He is currently a coordinator of the Laboratory of Cancer and Neurobiology, Center for Experimental Research, Hospital of Clinics of Porto Alegre. He has 275 publications to his credit. His expertise are in Biomedical Science, Cell Culture, and Cancer Biology.

rafaelroesler@hcpa.edu.br rafael.roesler@pq.cnpq.br
cctr_ebm_xu_001 Xu Cheng-Xiong Cancer Center Third Military Medical University Chongqing China

Dr. Xu is a professor at Daping Hospital and Research Institute of Surgery, Third Military Medical University, China. He received Ph.D from Seoul National university of Korea. He completed his postdoctoral training in the Department of Molecular Oncology at Moffitt Cancer Center and Research Institute. His research interests include non-coding RNA function in development and progression of cancer and the development and evaluation of novel therapies for cancer.

xuchengxiong@hanmail.net 18723070566@163.com
cctr_ebm_argiles_001 Argiles Josep M. Departament de Bioquímica i Biologia Molecular Universidad de Barcelona Barcelona Spain

Professor Josep M. Argiles was born in Barcelona, Catalonia, Spain in 1956 and completed his undergraduate studies in Biology at the University of Barcelona graduating with a First Class Honours Degree and Special Prize for the best B.Sc. (1979). In 1981 he received his Doctorate in Biochemistry from the same university with Cum Laude obtaining the Prize for the best doctorate of that year. In 1987 he undertook further postdoctoral training in the Laboratory of Metabolism and Molecular Biology at the National Institutes of Health, Bethesda, Maryland. He later became Full Professor of Biochemistry and Molecular Biology of Cancer at the Faculty of Biology, University of Barcelona, and then became the leader of a research group interested in cancer cachexia.

jargiles@ub.edu
cctr_ebm_sinicrope_001 Sinicrope Frank A. Mayo Comprehensive Cancer Center Mayo Clinic Rochester MN USA

Frank A. Sinicrope, is Professor of Medicine and Oncology at Mayo Clinic, Co-leader of the GI cancer program at the Mayo Clinic Comprehensive Cancer Center, Director for GI Translational Research for the North Central Cancer Treatment Group legacy studies, member of the GI Cancer Steering Committee of the National Cancer Institute, and vice-chair of the Cancer Prevention Committee and GI Committee of the Alliance for Clinical Trials in Oncology. Dr. Sinicrope is a board-certified medical oncologist and gastroenterologist, a recognized leader in molecular-based risk stratification of colon cancer and conducts research on experimental therapeutics approaches to reverse drug resistance.

sinicrope.frank@mayo.edu
cctr_ebm_d-liao_001 Liao Daiqing Department of Anatomy and Cell Biology University of Florida College of Medicine Gainesville FL USA

Daiqing Liao, Ph.D., conducted his postdoctoral training at Yale University School of Medicine and is currently an Associate Professor at University of Florida College of Medicine and a member of UF Health Cancer Center. The research in his laboratory focuses on cancer epigenetics, metabolism, and signaling pathways as well as development of small molecule therapeutics targeting lysine acetyltransferases (HATs), deacetylases (HDACs), and metabolism for cancer therapy.

dliao@ufl.edu
cctr_ebm_storz_001 Storz Peter Department of Cancer Biology Mayo Clinic Jacksonville Jacksonville FL USA

Peter Storz, Ph.D. is an Associate Professor at the Mayo Clinic. He obtained his Ph.D. from the University of Stuttgart, Germany, and was a postdoctoral fellow and instructor at the Beth Israel Deaconess Medical Center/Harvard Medical School in Boston, before he joined Mayo Clinic. Work in his laboratory focuses on inter- and intracellular signaling that leads to development and progression of pancreatic cancer. Specific interests are to understand the roles of acinar-to-ductal metaplasia and immune cell infiltration in these processes.

storz.peter@mayo.edu
cctr_ebm_grassilli_001 Grassilli Emanuela Department of Medicine and Surgery University of Milano-¬Bicocca Monza Itlay

Dr. Grassilli received her Ph.D. degree from the University of Modena, Italy, and pursued her post-doctoral research at Thomas Jefferson University, Philadelphia and European Institute of Oncology, Milan, studying the molecular mechanisms of apoptosis and their relevance in the response to chemotherapy. More recently, she co-founded Bionsil, a spin-off of the University of Milano-Bicocca, Italy, aimed at identifying and characterizing novel targets for molecular diagnosis and therapy of drug-resistant cancers. From 2014 she is Assistant Professor at the University of Milano-Bicocca where she continues her work on p65BTK, a novel Bruton’s Tyrosine isoform previously identified as a new target of therapy in colon cancers.

emanuela.grassilli@unimib.it
cctr_ebm_g-xu_001 Xu Guoxiong Department of Oncology Fudan University Shanghai China

Prof. Guoxiong Xu (MD, PhD) is a Scientist and Director of Center Laboratory in Jinshan Hospital, Fudan University, Shanghai, China. He obtained his PhD degree in Biology from York University in Canada. Dr. Xu is a molecular and cell biologist and has a proven track record on the molecular biology of cancer. He has presented his work in many national and international scientific conferences. His research works are supported by grants from the National Natural Science Foundation of China, Natural Science Foundation of Shanghai, Science and Technology Commission of Shanghai Municipality, and Shanghai Municipal Commission of Health and Family Planning.

guoxiong.xu@fudan.edu.cn
cctr_ebm_j-wu_001 Wu Jie Department of Pathology University of Oklahoma Health Sciences Center Oklahoma Ok USA

Dr. Wu is a Professor in the Department of Pathology and the Peggy and Charles Stephenson Endowed Chair in Cancer Translational Research at the University of Oklahoma Health Sciences Center. Recently, Dr. Wu discovered recurrent JAK1 truncating mutations in endometrial cancer and frequent JAK2 deletion in non-small cell lung cancer (NSCLC) involving tumor immune evasion, and as a potential mechanism of resistance to immune checkpoint therapy. Dr. Wu has authored 80 original research papers plus additional review articles and book chapters. He has served on National Institutes of Health (NIH), NCI, DOD, and Department of Veterans Affairs (VA) grant review panels.

jie-wu@ouhsc.edu
cctr_ebm_nath_001 Nath Kavindra Department of Radiology University of Pennsylvania Philadelphia PA USA

Kavindra Nath is a Research Assistant Professor at the University of Pennsylvania, Perelman School of Medicine, Department of Radiology, Molecular Imaging Laboratory. He did his M.S. in Biochemistry, and Ph.D. in Magnetic Resonance Imaging and Spectroscopy (MRI/MRS). In Ph.D. His current research at University of Pennsylvania is utilizing multi-nuclear (1H, 31P, 13C) MRS and other techniques in vitro and in vivo in order to delineate the mode of action of various monocarboxylate transport (MCTs), mitochondrial pyruvate carrier (MPC) and electron transport chain (ETC) inhibitors, which distinguishes normal cells from malignant cells and potentiates the activities of various chemotherapeutic drugs, hyperthermia and radiation therapy in a variety of human cancers.

Kavindra.Nath@uphs.upenn.edu
cctr_ebm_stylli_001 Stylli Stanley Department of Surgery The University of Melbourne Melbourne Australia

Dr Stanley Stylli is a cancer research scientist at the Department of Neurosurgery, The Royal Melbourne Hospital and an Honorary Fellow of the Department of Surgery (RMH) at The University of Melbourne, Australia. He received his Master of Science and PhD degrees from the University of Melbourne. His research interests include glioma biology, invasion and identifying novel therapeutic targets for glioma. Currently he is investigating the influence of invadopodia in glioma invasion, the response of invadopodia to various therapeutic approaches and the role of tumour-derived exosomes (TEX) for invadopodia biogenesis in glioma.

Stanley.Stylli@mh.org.au
cctr_ebm_krysko_001 Krysko Dmitri V. Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences Ghent University Ghent Belgium

Dmitri V. Krysko graduated from the Saratov State Medical University (Russia) in 1998 and then he moved to Belgium, where, in 2006, he obtained the Ph.D. degree from the Ghent University (Belgium). Dr. Krysko worked as a FWO Postdoctoral Scientist in the lab of Prof. Vandenabeele (VIB-Ghent University). From October 2016 Dr. Krysko has been appointed as Associate Professor at the Department of Basic Medical Sciences at Faculty of Medicine and Heath Sciences in Ghent University and a group leader of the CRIG (Cancer Research Institute Ghent). Dr. Krysko received several awards for his scientific work and serves as an Editorial Board Member of “Apoptosis” and “Mediators of Inflammation”. He published more than 60 articles in peer-reviewed international journals.

Dmitri.Krysko@ugent.be
cctr_ebm_w-han_001 Hann Hie-Won Liver Disease Prevention Center Thomas Jefferson University Hospital Philadelphia PA USA

Following Oncology Fellowship at Sidney Farber Cancer Institute, Dr. Won Hann joined Baruch Blumberg, the Nobel Laureate for discovery of HBV, at Fox Chase Cancer Center and worked on HBV, HCC, cancer enhancing effects of iron and anti-tumor effect of deferoxamine. Her new discovery included serum ferritin as the tumor and prognostic marker for neuroblastoma. Since 1988, she as the tenured Professor of Medicine and Director of Liver Disease Prevention Center at Thomas Jefferson University Hospital, has continued work on HBV as the Site Principal Investigator of 32 clinical trials evaluating anti-HBV agents (Lamivudine, Adefovir, Telbivudine, Entecavir, Tenofovir and TAF (Tenofovir alafenamide).

hie-won.hann@jefferson.edu
cctr_ebm_galigniana_001 Galigniana Mario D. Department of Biological Chemistry University of Buenos Aires Buenos Aires Argentina

He studied the biological role of two Hsp90-binding immunophilins, FKBP51 and FKBP52. He postulated a novel model for the mechanism of action of steroid receptors, where FKBP52 links the receptor-Hsp90 complex to motor proteins favouring receptor retrotransport on cytoskeletal tracts, its passage through the nuclear pore and transcriptional activation. FKBP51 antagonizes these effects. The model was extended to other factors (HSF1, p53, NF-kB) and proposes that the FKBP52/FKBP51 expression ratio regulates the final biological response of factors with pleiotropic action. He also demonstrated that both immunophilins regulate neurodifferentiation, and have identified FKBP51 as a novel mitochondrial factor. It shows antiapoptotic action which is overexpressed in tumor cells and enhances telomerase activity.

mgaligniana@conicet.gov.ar mgali@qb.fcen.uba.ar
cctr_ebm_choy_001 Choy Edwin Department of Medical Oncology Harvard Medical School Boston MA USA

Dr. Choy is the Director of Sarcoma Research at the Division of Hematology Oncology at MGH and Assistant Professor in Medicine at Harvard Medical School. He specialized in the medical management of patients with sarcomas, gastrointestinal stromal tumors, chordomas, and desmoid tumors. He works closely with a team of world class surgical, orthopedic, and radiation oncologists as well as connective tissue pathologists and radiologists to provide optimal care for his patients. He directs a clinical trials program at the MGH Center for Sarcoma and Connective Tissue Oncology that includes 9-12 active phase I-III clinical trials.

echoy@mgh.harvard.edu
cctr_ebm_ablin_001 Ablin Richard J. Department of Pathology University of Arizona College of Medicine Arizona AZ USA

Dr. Ablin is a Professor at University of Arizona College of Medicine, Arizona Cancer Center and BIO5 Institute and President, Robert Benjamin Ablin Foundation for Cancer Research, founded in memory of his father. He was honored as recipient of the First Award for Scientific Excellence. He discovered prostate-specific antigen (PSA), and was a nominee for the Lasker Award. He is a pioneer of cryosurgery and the concept of “cryoimmunotherapy” for the treatment of cancer. He is a member of Sigma Xi, Phi Beta Kappa and numerous professional societies. He has been an invited speaker, contributed numerous articles, co-editor of the book series Cancer Metastasis -Biology and Treatment and serves on the editorial board of several journals.

ablinrj@email.arizona.edu
Assimakopoulos Dimitrios Department of Otorhinolaryngology University of Ioannina Ioannina Greece dassimak@cc.uoi.gr dassimak@uoi.gr Bar-Eli Menashe Department of Cancer Biology University of Texas MD Anderson Cancer Center Houston TX USA mbareli@mdanderson.org cctr_ebm_bertino_001 Bertino Joseph R. The Cancer Institute of New Jersey UMDNJ-Robert Wood Johnson Medical School New Brunswick NJ USA

Joseph R. Bertino, MD, is Professor at UMDNJ-Robert Wood Johnson Medical School and director of the school's Cancer Institute of New Jersey Bertino in New Brunswick. He has been internationally recognized for his role in finding curative treatments for leukemia and lymphoma. During his academic career. He received several awards and honors for his research accomplishments. Currently, he is the associate editor for Cancer Research and Clinical Cancer Research and also the editor of the Encyclopedia of Cancer. He is the author and co-author of more than 400 scientific publications. His research elucidated the mechanisms of methotrexate resistance in experimental models, and in cancer patients.

bertinoj@umdnj.edu bertinoj@cinj.rutgers.edu
cctr_ebm_bouffet_001 Bouffet Eric Department of Paediatrics The Hospital for Sick Children Toronto ON Canada

Dr. Eric Bouffet is Professor of Paediatrics in the University of Toronto, Garron Family Chair in Childhood Cancer Research, Associate Senoior Scientist at the Research Institute, and Head of the Neuro-oncology Section in the Division of Haematology/Oncology at The Hospital for Sick Children, Toronto. His research interests are in the area of novel treatments and clinical trials in children with brain tumours. He is author or co-author of over 380 peer-reviewed manuscripts and author/co-author on numerous book chapters in the field of neuro-oncology. In 2016, he became the President of the International Society of Paediatric Oncology (SIOP).

eric.bouffet@sickkids.ca
cctr_ebm_bukowski_001 Bukowski Ronald M. Cleveland Clinic Taussig Cancer Center Cleveland Clinic Foundation Cleveland OH USA

Dr. Bukowski is an emeritus staff at the Cleveland Clinic Foundation, and was recently the Deputy Director of the Cleveland Clinic Taussig Cancer Center and Director of the Experimental Therapeutics at the Cleveland Clinic Cancer Center. He held the James Zito Chair in Cancer Research at the Taussig Cancer Center from 2001 to 2008. Dr. Bukowski is a fellow of the American College of Physicians and a member of numerous professional societies, including the American Society of Clinical Oncology, and the American Society of Hematology. He is a lifelong researcher with interests in immunotherapy, the immunology and biology of renal cell carcinoma, and new drug development and investigation. Currently Dr. Bukowski is a member of the board of directors of the Kidney Cancer Association, & its medical committee.

bukowsr@cc.ccf.org bukow464@sbcglobal.net
Carruba Giuseppe Department of Oncology ARNAS-Civico Palermo Italy lucashbl@unipa.it cctr_ebm_clarke_001 Clarke Robert Department of Oncology Georgetown University Medical Center Washington DC USA

Robert Clarke, Ph.D., D.Sc. leads Georgetown University Medical Center’s high performance research community, expanding its extramural funding and promoting the efforts of its faculty. Also, he works in collaboration with the Georgetown University Graduate School of Arts and Sciences to cultivate and strengthen the research components of the University’s graduate programs and the quality of graduate biomedical education. Clarke is co-director of the Georgetown-Lombardi Comprehensive Cancer Center breast cancer program, a professor in the Department of Oncology, and an internationally known breast cancer researcher.

clarker@georgetown.edu
cctr_ebm_cooney_001 Cooney Kathleen A. Department of Internal Medicine University of Utah School of Medicine Salt Lake City MI USA

Kathleen A. Cooney, MD, is Professor and Chair of the Department of Internal Medicine, H.A. and Edna Benning Presidential Endowed Chair, at the University of Utah. She received her M.D. degree from the University of Pennsylvania Perelman School of Medicine at Philadelphia in 1984. Her research led to the important discovery of a recurrent mutation in the HOXB13 gene that increases the chances of being diagnosed with prostate cancer. As an oncologist, Cooney focuses on treating advanced forms of prostate cancer.

kathleen.cooney@hsc.utah.edu
cctr_ebm_daly_001 Daly John M. School of Medicine Temple University Philadelphia PA USA

Dr. John M. Daly was Dean of the School of Medicine at Temple University from 2002 to 2011. Prior to that, he had been the Stimson Professor and Chairman of the Department of Surgery at the New York Presbyterian-Cornell Medical Center in New York City since 1993. He was previously Professor of Surgery and Chief of the Division of Surgical Oncology at the University of Pennsylvania. Dr. Daly is an internationally renowned surgeon whose clinical work and research are in the fields of surgical oncology, metabolism, and nutrition, authoring more than 300 peer-reviewed publications and 100 book chapters. He has served on the editorial boards of dozens of medical publications.

johndaly@temple.edu
cctr_ebm_danforth_001 Danforth David N. Jr National Cancer Institute National Institute of Health (NIH) Bethesda MD USA

Dr. Danforth received his M.S. degree in physiology from the University of New Mexico, Albuquerque, NM and M.D. degree from Northwestern University, Chicago IL. He received his residency training in general surgery at the New York Hospital-Cornell medical Center in NYC, and received fellowship training in surgical oncology at the National Cancer Institute, NIH, Bethesda, MD, and the M.D. Anderson Hospital and Tumor Institute, Houston TX. He is a Staff Clinician in the Surgery Branch, National Cancer Institute, NIH, Bethesda. He has published more than 100 scientific publications in peer-reviewed journals.

david_danforth@nih.gov DanfortD@mail.nih.gov
cctr_ebm_dubeau_001 Dubeau Louis Professor of Pathology Medical, Director of Molecular Pathology University of Southern California, Keck School of Medicine Los Angeles CA USA

Louis Dubeau received his M.D.C.M. in 1979 and his Ph.D. in biochemistry in 1981, both from McGill University in Canada. He moved to University of Southern California in 1985 to study cancer biology and epigenetics under the sponsorship of Dr. Peter Jones. He became assistant professor in the Department of Pathology at University of Southern California in 1989, where he is currently Professor of Pathology and Medical Director of Molecular Pathology. His research is focused on the biology of ovarian carcinoma. Significant contributions include the understanding of the site of origin of these tumors and the mechanisms underlying their hormonal and genetic risk factors.

ldubeau@usc.edu
cctr_ebm_deiry_001 El-Deiry Wafik S. Department of Medicine University of Pennsylvania Philadelphia PA USA

Wafik El-Deiry, MD, PhD, FACP is the Deputy Cancer Center Director for Translational Research, co-Leader of the Molecular Therapeutics Program, Professor of Oncology, and the William Wikoff Smith Endowed Chair in Cancer Research at Fox Chase Cancer Center in Philadelphia. He earned MD/PhD degrees from University of Miami School of Medicine and completed internal medicine residency and medical oncology fellowship at Johns Hopkins. He discovered cyclin-dependent kinase (CDK) inhibitor p21(WAF1) as a p53 target gene and cell cycle inhibitor. This is the most highly cited original work published in Cell. He has >350 peer-reviewed publications and edited 5 books. He is an elected member of the Johns Hopkins University Society of Scholars.

wafik@mail.med.upenn.edu
cctr_ebm_ford_001 Ford James M. School of medicine Stanford University Stanford CA USA

Dr. Ford is a medical oncologist and geneticist at Stanford, devoted to studying the genetic basis of breast and GI cancer development, treatment and prevention. He received his M.D. degree from the School of Medicine in 1989. He is currently Professor of Medicine (Oncology) and Genetics, and Director of the Stanford Cancer Genetics Clinic and the Cancer Genomics Program at the Stanford University Medical Center. His clinical interests include the diagnosis and treatment of patients with a hereditary pre-disposition to cancer. He is an editor of numerous scientific journals, including Cancer Research, DNA Repair, and PLoS Genetics. He has recently been named the founding Editor-in-Chief of JCO Precision Oncology.

jmf@stanford.edu
cctr_ebm_friedman_001 Friedman Henry S. Duke University Medical Center Durham NC USA

Dr. Henry S. Friedman is an internationally renowned academic adult and pediatric neuro-oncologist who helps to lead The Preston Robert Tisch Brain Tumor Center at Duke University. He is the author of more than 500 peer reviewed articles, reviews, and book chapters and has presented extensively at both international and national meetings. He is the senior editor of CNS Oncology, was the Associate Editor for the Neuro-Oncology Section of Cancer for 15 years and is a reviewer of over 25 academic journals.

fried003@mc.duke.edu
cctr_ebm_Giaccia_001 Giaccia Amato J. Department of Oncology Stanford University Stanford CA USA

Dr. Amato J. Giaccia obtained his Ph.D. in Pathology/Molecular Biology from the University of Pennsylvania in Philadelphia. He is a Professor of Radiation Oncology, Associate Chair for Research & Director of the Division of Radiation & Cancer Biology in the Department of Radiation Oncology. He also is the Director of Basic Science at the Stanford Cancer Institute and heads the Radiation Biology Program in Stanford’s Cancer Center. He co-authored the sixth & seventh editions of the textbook, “Radiation Biology for the Radiologist,” with Professor Eric Hall from Columbia. In addition, he is currently the “Jack, Lulu and Sam Willson Professor in Cancer Biology” in the Stanford University School of Medicine.

giaccia@stanford.edu
cctr_ebm_giavazzi_001 Giavazzi Raffaella IRCCS-Mario Negri Institute for Pharmacological Research Milan Italy

Dr Raffaella Giavazzi obtained a doctorate (PhD) in Pharmacology from the University of Milan, Italy. She holds the Qualification of Professor in General Pathology and in Applied Biology. She was a post-doc Fellow at NCI-FCRDC, Frederick, (USA) and Assistant Professor at MD Anderson Hospital, Houston (USA). Currently Dr Giavazzi is Head of the Laboratory of Biology and Treatment of Metastasis at the Mario Negri Institute for Pharmacological Research and she is in the Board of Directors at the University of Trento, Italy. She has published approximately 200 articles in the field of Cancer Research and communicated approximately 400 studies in national and international congresses.

giavazzi@marionegri.it
cctr_ebm_ilson_001 Ilson David H. Memorial Sloan-Kettering Cancer Center New York NY USA

Dr. Ilson is attending physician and member at Memorial Hospital, and professor of medicine at Weill-Cornell Medical College. His research interest is upper gastrointestinal cancer with a focus on esophageal cancer. His research focuses on the study of new agents in advanced esophageal cancer and in combined modality therapy. He sits on U.S. NCCN Gastric Cancer guideline panel, and the GI Cancer committees of Alliance/CALGB and NRG/RTOG. He is the former chair of the U.S. NCI Esophageal and Gastric Cancers Clinical Trial Task Force.

ilsond@mskcc.org
cctr_ebm_incalci_001 Incalci Maurizio D. Department of Oncology Istituto di Ricerche Farmacologiche Mario Negri Milan Italy

Maurizio D'Incalci obtained his Medical Degree cum Laude from the University of Milan (1978). Then he specialized in Pharmacology in 1979 and in Oncology in1981. He worked in the Molecular Pharmacology Laboratory, NCI, Bethesda (1983-84). He is chief of the Cancer Chemotherapy Laboratory since 1986 and of the Oncology Department since 1996 at the Mario Negri Institute. He has been a member of the board of several National and International organizations as EORTC, SENDO, and SIC and he is currently a member of AIRC, MaNGO, Fondazione Mattioli, and Fondazione Buzzi. He is the author of more than 500 papers on cancer pharmacology and of several book chapters.

dincalci@marionegri.it
Ito Yasuhiro Department of Surgery Kuma Hospital Kobe Japan ito01@kuma-h.or.jp cctr_ebm_kaina_001 Kaina Bernd Institute of Toxicology University of Mainz Mainz Germany

Dr. Bernd Kaina obtained his Ph.D. in genetics in 1976 from the University of Halle, Germany. He completed his postdoctoral training from the Institute of Genetics in Gatersleben and continued his studies on DNA repair at the Department of Molecular Biology in Leiden, the Netherlands, at the German Cancer Research Center in Heidelberg and, as a Heisenberg fellow, at the Department of Genetics of the Nuclear Research Center in Karlsruhe, Germany. In 1993, he was appointed a full professor for molecular toxicology at the Institute of Toxicology of the University of Mainz, then became the director of the institute in 2003. He is the author of more than 280 scientific publications and serves as editorial board member and reviewer for several scientific journals.

kaina@mail.uni-mainz.de
Kalluri Raghu Department of Cancer Biology University of Texas MD Anderson Cancer Center Boston MA USA rkalluri@bidmc.harvard.edu Lunec John Northern Institute for Cancer Research University of Newcastle upon Tyne Newcastleupon Tyne UK john.lunec@ncl.ac.uk Mckeage Mark J. Department of Pharmacology and Clinical Pharmacology University of Auckland Auckland New Zealand m.mckeage@auckland.ac.nz Mukhtar Hasan Department of Dermatology University of Wisconsin-Madison Madison WI USA hmukhtar@dermatology.wisc.edu acctra_ebm_narayanan_001 Narayanan Ramaswamy Department of Biological Sciences Florida Atlantic University Boca Raton FL USA

Ramaswamy Narayanan earned his Ph.D. in biochemistry in 1980 from the National University of Dublin, Ireland. He has worked at the NCI, CDC, the Yale University, Memorial Sloan Kettering Cancer Center, and at the Hoffmann-La Roche, Inc. He has published over 140 peer-reviewed publications and numerous book chapters. He is a Professor at Florida Atlantic University for the last seventeen years, where his work has led to two issued patents and the first Biotech spin-off company for the University. His research revolves around the genomics of cancer and other diseases.

rnarayan@fau.edu
Notario Vicente Professor of Radiation Medicine, and of Biochemistry and Molecular & Cellular Biology Georgetown University Medical Center Washington DC USA notariov@georgetown.edu Reaman Gregory H. Center for Drug Evaluation and Research Washington DC USA greaman@childrensoncologygroup.org gregory.reaman@fda.hhs.gov cctr_ebm_shamsuddin_001 Shamsuddin Abul K. Department of Pathology University of Maryland School of Medicine Baltimore MD USA

Dr. AbulKalam M. Shamsuddin is Professor of Pathology at the University of Maryland School of Medicine in Baltimore. He received his medical degree from Dhaka University, and PhD from University of Maryland. He is the pioneering scientist to demonstrate the anti-cancer and immune enhancing function of inositol and inositol hexaphosphate (www.ip-6.net). Dr. Shamsuddin has published several books, many book-chapters and numerous scientific papers. He serves on the editorial board of several cancer related journals; and is a highly sought after speaker in international scientific meetings.

shams@som.umaryland.edu research@ip-6.net
Sherbet Gajanan V. School of Electrical and Electronic Engineering University Newcastle Upon Tyne Newcastle upon Tyne UK Gajanan.Sherbet@newcastle.ac.uk Soffietti Riccardo Division of Neuro-Oncology/Neurology and Center for Neuro-Oncology University of Turin Turin Italy riccardo.soffietti@unito.it Spandidos Demetrios A. Medical School University of Crete Crete Greece spandidos@spandidos.gr Stein Gary S. University of Massachusetts Medical School Worcester MA USA Gary.Stein@uvm.edu Gary.Stein@umassmed.edu Stewart Clinton F. Department of Pharmaceutical Sciences St. Jude Children's Research Hospital Memphis TN USA clinton.stewart@stjude.org Taketo Makoto M. Division of Experimental Therapeutics Kyoto University Hospital-iACT Kyoto Japan taketo@mfour.med.kyoto-u.ac.jp Xiang Jim College of Medicine University of Saskatchewan Saskatoon SK Canada jim.xiang@saskcancer.ca cctr_ebm_bakin_001 Bakin Andrei V. Department of Cancer Genetics and Genomics Roswell Park Cancer Institute Buffalo NY USA

Dr. Andrei V. Bakin obtained his Ph.D. degree (1990) in Molecular Biology from Moscow State University, Moscow, Russia. Since 2003, Dr. Bakin has been Associate/Assistant Professor of Oncology at Roswell Park Cancer Institute, Buffalo, NY, USA. Additionally, since 2014, he has also been performing the role of Research Associate/Assistant Professor, State University of New York (SUNY) at Buffalo, Buffalo, NY, USA. Dr. Bakin, as an author/co-author, has published more than 50 articles in various journals, having a noteworthy number of total citations, i.e. over 5,000. His professional memberships include the following: American Association for Cancer Research (AACR) (1996-present), Metastasis Research Society (2004-present), American Society for Cell Biology (2004-present), and Tumor Microenvironment Society (2006-present).

Andrei.Bakin@RoswellPark.org
cctr_ebm_botelho_001 Botelho Monica C. Department of Health Promotion and Chronic Diseases National Institute of Health Porto Portugal

Monica C. Botelho has completed her Ph.D with Distinction in 2011 from the Faculty of Medicine of Porto University. She is the Head of Lab of Health Promotion and Chronic Diseases Unit of the National Institute of Health (INSA) Dr. Ricardo Jorge, is a premier health service organization in Porto, Portugal and Researcher at Instituto of Investigação e Inovação em Saúde (i3S), Group of Metabolism, Nutrition and Endocrinology, of Porto University, Portugal. She has published more than 50 papers and has an H Index of 17 (Google Scholar metrics). Her areas of expertise include: Neglected Tropical Diseases associated Cancers and Infertility, Molecular carcinogenesis of schistosome associated squamous cell carcinoma of the bladder with mouse experiments as models of carcinogenesis, Effects of schistosoma-derived estrogenic molecules on cell lines and the accumulation and biodistribution of these molecules in animal models, and their possible carcinogenic effect and schistosomiasis associated catechol-estrogens as biomarkers of cancer and infertility.

monica.botelho@insa.min-saude.pt monicabotelho@hotmail.com
cctr_ebm_mita_001 Mita Monica Department of Clinical Oncology Samuel Oschin Comprehensive Cancer Institute Los Angeles CA USA

Dr. Monica M. Mita is a medical oncologist in Los Angeles, California and is affiliated with multiple hospitals in the area, including Cedars-Sinai Medical Center, Los Angeles, CA, USA, and UCLA Medical Center, Santa Monica, CA, USA. She received her medical degree from Carol Davila University of Medicine and Pharmacy and has been in practice for more than 20 years. She is currently co-director of the Experimental Therapeutics Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA. Her main research focus is on phase I clinical trials in oncology, novel drugs, and targeted therapies, with more than 50 peer-reviewed articles published. In addition, her clinical areas focus on breast cancers and sarcomas.

Monica.Mita@cshs.org
Associate Editorial Board Members cctr_ebm_Hettie_001 Hettie Kenneth S. Orcid Department of Radiology Stanford University School of Medicine Stanford CA USA

Dr. Hettie is an NCI/NIH Ruth L. Kirschstein NRSA Fellow (PI/PD) in the Departments of Radiology and Otolaryngology-Head & Neck Surgery within the School of Medicine at Stanford University that specializes in the design, development, and implementation of near-infrared-I/II peptidyl-, nucleic acid-, and immuno-based activatable bio-/molecular probes, biosensors, theranostics, and nanoparticles targeting biomarkers of brain cancers and their tumor microenvironment for their early detection, direct visualization, and surgical removal via utilizing image-guided surgery. He focuses on their rational design, bio-/chemical synthesis, and bio-/analytical evaluation of novel diagnostics and therapeutics in basic science research, preclinical, and clinical setting.

0000-0002-0607-7944 55783013800 khettie@stanford.edu
cctr_ebm_mandal_001 Mandal Sudip K. Department of Pharmaceutical Chemistry Dr. B. C. Roy College of Pharmacy and Allied Health Sciences Durgapur India https://scholar.google.co.in/citations?user=vniEruoAAAAJ&hl=en

Dr. Sudip Kumar Mandal is working as a faculty at Dr. B. C. Roy College of Pharmacy and A.H.S., Durgapur, India. His research interests focus on discovery and development of bioactive organic compounds and related derivatives from synthetic routes and natural sources against inflammation, pain, arthritis, microorganism, and cancer. He has published 30 articles in peer reviewed journals of repute. He was also invited as the Keynote Speaker at the International Conference organized by Kafrelsheikh University, Egypt in 2019. He is honoured as an Editorial Board Member in many reputed journals and serves as an Editor of Egyptian Journal of Chemistry.

gotosudip79@gmail.com
cctr_ebm_kumar-m-ah_001 Kumar Manish Orcid Department of Biology S.D. College Punjab India

Dr. Manish Kumar is an Assistant Professor in Botany at S.D. College, Barnala, Punjab, India. Dr. Kumar is M.Sc., M.Phil. & PhD in Botany from Guru Nanak Dev University and has qualified CSIR-NET and GATE. He has over 3 years of teaching and 9 years of research experience and his areas of specialization include Cancer Chemoprevention, Genetic Toxicology, Environmental mutagenesis and Medicinal plants. He has published more than 30 research articles in journals and books of international repute with a cumulative impact factor of more than 35. He has been a member of the editorial board and reviewer board of many journals. He has been recognized for outstanding contribution in Reviewing for the Journal “Journal of Traditional and Complementary Medicine (Elsevier)” in 2017. He has been a member of various national and international conferences/programs. Recently, Dr. Kumar has edited a book with Bentham Science Publishers.

kumarmanish639@gmail.com 0000-0001-7402-2665 57202148322
cctr_ebm_m-sedic_001 Sedic Mirela Department of Biotechnology University of Rijeka Rijeka Croatia

Dr. Mirela Sedic is Associate Professor at the University of Rijeka Department of Biotechnology in Croatia. She has authored more than 30 scientific publications in peer-reviewed journals including high-impact journals such as Molecular Cancer, The Journal of Pathology, Molecular Cancer Therapeutics, Journal of Medicinal Chemistry, and Cancer Treatment Reviews. She is co-author of book chapters in Bioinformatics and Drug Discovery (Humana Press, 2012), Personalized Medicine: A New Medical and Social Challenge (Springer International Publishing, 2016), and has one international patent (WO/2010/052510). Her main research interests include cancer biology and signalling, experimental oncology, chemoresistance, sphingolipids in cancer and proteomics.

msedic@biotech.uniri.hr
cctr_ebm_s-nara_001 Nara Seema Department of Biotechnology Motilal Nehru National Institute of Technology Allahabad India

Dr. Seema Nara is an Associate Professor in Department of Biotechnology, MNNIT Allahabad, India since April 2009. She has completed her doctorate from Indian Institute of Technology Delhi, India in 2009 in the field of Immunodiagnostics. She has been working in the area of developing diagnostic solutions for detecting pathogens, cancer biomarkers, food/environment contaminants using antibodies and aptamers. Her group is actively engaged in exploring the applications of nanostructures diagnostics as well as therapeutics. She has successfully completed extramural projects in the area of her interest. Her research outcome is published in International journals of repute, as book chapters and is also evident from 03 filed patents.

seemanara@mnnit.ac.in
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