Abstract
CD4+CD25+ T cells are essential for maintenance of self-tolerance and therefore have been referred to as regulatory T cells (Treg). Experimental tumor models revealed that Treg are potent inhibitors of an anti-tumor immune response. Treg are expanded in human cancer. Currently, a variety of strategies for the induction of a specific anti-tumor immune response are tested in preclinical and clinical settings. Biochemical strategies modifying and/or depleting Treg in cancer patients for an enhancement of vaccine-based therapeutic concepts will be discussed in detail in this review.
Keywords: Biochemical modification, regulatory T cell, immune evasion, cancer
Mini-Reviews in Medicinal Chemistry
Title: Regulatory T Cells in Cancer Biology: A Possible New Target for Biochemical Therapies
Volume: 6 Issue: 5
Author(s): Dominik Wolf, Holger Rumpold and Anna-Maria Wolf
Affiliation:
Keywords: Biochemical modification, regulatory T cell, immune evasion, cancer
Abstract: CD4+CD25+ T cells are essential for maintenance of self-tolerance and therefore have been referred to as regulatory T cells (Treg). Experimental tumor models revealed that Treg are potent inhibitors of an anti-tumor immune response. Treg are expanded in human cancer. Currently, a variety of strategies for the induction of a specific anti-tumor immune response are tested in preclinical and clinical settings. Biochemical strategies modifying and/or depleting Treg in cancer patients for an enhancement of vaccine-based therapeutic concepts will be discussed in detail in this review.
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Cite this article as:
Wolf Dominik, Rumpold Holger and Wolf Anna-Maria, Regulatory T Cells in Cancer Biology: A Possible New Target for Biochemical Therapies, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876230
DOI https://dx.doi.org/10.2174/138955706776876230 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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