Abstract
Background: Chitosan-based nano-biocomposite has received more and more attentions in the past few years because of the outstanding merits that chitosan is a natural polymer with biodegradable and biocompatible.
Objective: The purpose of the present study is to summarize the different preparation methods of chitosan-based nano-biocomposites, such as electrostatic interaction method, preparation of chitosan-based nano-biocomposites from modified chitosan using selfassembly technique, chemical crosslinking approach, metal ions coordination and metal nanoparticles compound methods. In addition, the applications of chitosan-based nanobiocomposites in wound dressing, drug delivery, tissue engineering and biosensors are also discussed.
Results: The results show that chitosan-based nano-biocomposites based on nanoparticles or nanohydrogel that can deliver drugs directly to cancer cells at a sustained and controlled rate may provide better efficacy and lower toxicity for the treatment of cancer. Furthermore, chitosan-based nano-biocomposites can enhance the properties of unmodified chitosan and improve the amphipathy, physical and mechanical properties of chitosan and produce new biological functions.
Conclusion: It is believed that the rapid development of nano-science and technology must brought broad application prospects for the chitosan-based nano-biocomposites.
Keywords: Chitosan, nano-biocomposites, medicine, pharmaceutics, application, preparation.
Current Organic Chemistry
Title:Chitosan-based Nano-biocomposites and their Applications in Medicine and Pharmaceutics
Volume: 22 Issue: 7
Author(s): Ziming Yang, Puwang Li, Andrew McDonagh*, Sidong Li, Mingzhe Lv, Yongzhen Li, Ziyang Yu and Changgen Feng*
Affiliation:
- Department of Chemical and Biomolecular Engineering, University of Technology Sydney, Sydney, NSW 2007,Australia
- Mechanics and Engineering Department, Beijing Institute of Technology, Beijing 100081,China
Keywords: Chitosan, nano-biocomposites, medicine, pharmaceutics, application, preparation.
Abstract: Background: Chitosan-based nano-biocomposite has received more and more attentions in the past few years because of the outstanding merits that chitosan is a natural polymer with biodegradable and biocompatible.
Objective: The purpose of the present study is to summarize the different preparation methods of chitosan-based nano-biocomposites, such as electrostatic interaction method, preparation of chitosan-based nano-biocomposites from modified chitosan using selfassembly technique, chemical crosslinking approach, metal ions coordination and metal nanoparticles compound methods. In addition, the applications of chitosan-based nanobiocomposites in wound dressing, drug delivery, tissue engineering and biosensors are also discussed.
Results: The results show that chitosan-based nano-biocomposites based on nanoparticles or nanohydrogel that can deliver drugs directly to cancer cells at a sustained and controlled rate may provide better efficacy and lower toxicity for the treatment of cancer. Furthermore, chitosan-based nano-biocomposites can enhance the properties of unmodified chitosan and improve the amphipathy, physical and mechanical properties of chitosan and produce new biological functions.
Conclusion: It is believed that the rapid development of nano-science and technology must brought broad application prospects for the chitosan-based nano-biocomposites.
Export Options
About this article
Cite this article as:
Yang Ziming , Li Puwang , McDonagh Andrew*, Li Sidong , Lv Mingzhe , Li Yongzhen , Yu Ziyang and Feng Changgen *, Chitosan-based Nano-biocomposites and their Applications in Medicine and Pharmaceutics, Current Organic Chemistry 2018; 22 (7) . https://dx.doi.org/10.2174/1385272821666170825120835
DOI https://dx.doi.org/10.2174/1385272821666170825120835 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The First Total Syntheses of the Diglycosides Virgaureoside A, of Solidago virgaurea L., and its Analogue iso-Virgaureoside A
Current Organic Synthesis Lipid-Based Systems for Delivery of Biological Macromolecules
Recent Patents on Nanomedicine Regeneration in a Degenerating Brain: Potential of Allopregnanolone as a Neuroregenerative Agent
Current Alzheimer Research p53 Regulation of Energy Metabolism and Mitochondria Regulation of p53 in Cancer Cells: An Insight into the Role of Manganese Superoxide Dismutase
Current Pharmaceutical Biotechnology The Worrying Trend of Diabetes Mellitus in Saudi Arabia: An Urgent Call to Action
Current Diabetes Reviews F508del-CFTR Rescue: A Matter of Cell Stress Response
Current Pharmaceutical Design Risk Factors for Suicide – An Alternative View
CNS & Neurological Disorders - Drug Targets The Evolving Therapeutic Approaches for Epstein-Barr Virus Infection in Immunocompetent and Immunocompromised Individuals
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94
Current Topics in Medicinal Chemistry Biomarkers of Chronic Kidney Disease - Mineral and Bone Disorder (CKD-MBD), A Review of Published Patents and Patent Applications
Recent Patents on Biomarkers Towards Standardized Stem Cell Therapy in Type 2 Diabetes Mellitus: A Systematic Review
Current Stem Cell Research & Therapy The Potential Anti-Tumorigenic and Anti-Metastatic Side of the Proprotein Convertases Inhibitors
Recent Patents on Anti-Cancer Drug Discovery A Catalytically Inactive Lys49 PLA2 Isoform from Bothrops jararacussu venom that Stimulates Insulin Secretion in Pancreatic Beta Cells
Protein & Peptide Letters Bombacaceae Between the Ethnomedical Uses and Pharmacological Evidences: A Review
The Natural Products Journal 68Ga/64Cu PSMA Bio-Distribution in Prostate Cancer Patients: Potential Pitfalls for Different Tracers
Current Radiopharmaceuticals Editorial [Hot Topic: Recent Developments and Future Directions in the Treatment of Systemic Rheumatic Diseases (Guest Editor: Minoru Satoh) ]
Endocrine, Metabolic & Immune Disorders - Drug Targets Genetic and Molecular Determinants of Atherosclerotic Plaque Instability
Current Vascular Pharmacology Sorafenib as a Salvage Therapy in FLT3-ITD Negative Relapse/ Refractory Acute Myeloid Leukemia
Anti-Cancer Agents in Medicinal Chemistry Deranged Metabolic Profile and Identification of Biomarkers in the Vitreous Humour of Patients with Proliferative Diabetic Retinopathy
Protein & Peptide Letters FoxO1 Inhibitors: The Future Medicine for Metabolic Disorders?
Current Diabetes Reviews