Abstract
Cancer is the manifestation of multiple dysregulated cellular pathways. Treatment protocols engaged in treating these diseases involve mainly the cell cycle regulating genes/proteins, DNA synthesis and repair, protein synthetic machinery, apoptotic and proliferation activity and cytoskeletal framework. Some of the traditional therapeutic strategies have over the years developed resistance making cure difficult to achieve. This paper analyzes the mechanisms employed by various cancers that render them resistant against therapeutic drugs.
Keywords: Cancer, drug, mutation, radiation, resistance, therapeutics.
Current Pharmaceutical Biotechnology
Title:Mechanisms of Resistance Against Cancer Therapeutic Drugs
Volume: 15 Issue: 12
Author(s): Shailja Chatterjee, Satyawan G. Damle and Anil K. Sharma
Affiliation:
Keywords: Cancer, drug, mutation, radiation, resistance, therapeutics.
Abstract: Cancer is the manifestation of multiple dysregulated cellular pathways. Treatment protocols engaged in treating these diseases involve mainly the cell cycle regulating genes/proteins, DNA synthesis and repair, protein synthetic machinery, apoptotic and proliferation activity and cytoskeletal framework. Some of the traditional therapeutic strategies have over the years developed resistance making cure difficult to achieve. This paper analyzes the mechanisms employed by various cancers that render them resistant against therapeutic drugs.
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Cite this article as:
Chatterjee Shailja, Damle G. Satyawan and Sharma K. Anil, Mechanisms of Resistance Against Cancer Therapeutic Drugs, Current Pharmaceutical Biotechnology 2014; 15 (12) . https://dx.doi.org/10.2174/1389201015666141126123952
DOI https://dx.doi.org/10.2174/1389201015666141126123952 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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