Abstract
The [1,4]benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]benzodiazepine from CNS acting drugs to anticancer agents. During last few decades, a large number of reports have appeared in the literature highlighting the anticancer activity of [1,4]benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]benzodiazepines as anticancer agent, their mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades till date.
Keywords: Anticancer, [1, 4]Benzodiazepines, DNA intercalating agents, Pyrrolo[1, 4]benzodiazepine, Antiarrhythmic agents, 2-Azidobenzoylchloride, Histone deacetylase inhibitors, Columbic interactions.
Mini-Reviews in Medicinal Chemistry
Title:Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review
Volume: 14 Issue: 3
Author(s): Rupinder Kaur Gill, Shiv Om Kaushik, Jasreen Chugh, Sumit Bansal, Anamik Shah and Jitender Bariwal
Affiliation:
Keywords: Anticancer, [1, 4]Benzodiazepines, DNA intercalating agents, Pyrrolo[1, 4]benzodiazepine, Antiarrhythmic agents, 2-Azidobenzoylchloride, Histone deacetylase inhibitors, Columbic interactions.
Abstract: The [1,4]benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]benzodiazepine from CNS acting drugs to anticancer agents. During last few decades, a large number of reports have appeared in the literature highlighting the anticancer activity of [1,4]benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]benzodiazepines as anticancer agent, their mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades till date.
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Cite this article as:
Gill Kaur Rupinder, Kaushik Om Shiv, Chugh Jasreen, Bansal Sumit, Shah Anamik and Bariwal Jitender, Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review, Mini-Reviews in Medicinal Chemistry 2014; 14 (3) . https://dx.doi.org/10.2174/13895575113139990081
DOI https://dx.doi.org/10.2174/13895575113139990081 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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