Abstract
The synthesis of novel compound libraries along with screening is a rapid and effective approach for the discovery of potential chemical agents, and it becomes an important method in pharmaceutical chemistry research. 1,3,4- oxadiazole derivatives as the typical heterocyclic compounds, exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel 1,3,4-oxadiazoles derivatives with antimicrobial, antitumor or antiviral activities during the past decade. In this review, we discussed the synthetic development of 1,3,4-oxadiazoles derivatives, and also the relevant bioactivity and their prospects as the potential chemical drugs.
Keywords: 1, 3, 4-oxadiazole, synthesis, antimicrobial, anticancer, antiviral, bioactivities.
Mini-Reviews in Medicinal Chemistry
Title:1,3,4-Oxadiazole Derivatives as Potential Biological Agents
Volume: 13 Issue: 12
Author(s): Juan Sun, Jigar A. Makawana and Hai-Liang Zhu
Affiliation:
Keywords: 1, 3, 4-oxadiazole, synthesis, antimicrobial, anticancer, antiviral, bioactivities.
Abstract: The synthesis of novel compound libraries along with screening is a rapid and effective approach for the discovery of potential chemical agents, and it becomes an important method in pharmaceutical chemistry research. 1,3,4- oxadiazole derivatives as the typical heterocyclic compounds, exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel 1,3,4-oxadiazoles derivatives with antimicrobial, antitumor or antiviral activities during the past decade. In this review, we discussed the synthetic development of 1,3,4-oxadiazoles derivatives, and also the relevant bioactivity and their prospects as the potential chemical drugs.
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Cite this article as:
Sun Juan, Makawana A. Jigar and Zhu Hai-Liang, 1,3,4-Oxadiazole Derivatives as Potential Biological Agents, Mini-Reviews in Medicinal Chemistry 2013; 13 (12) . https://dx.doi.org/10.2174/13895575113139990071
DOI https://dx.doi.org/10.2174/13895575113139990071 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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