Abstract
Some novel N-(benzo[d]thiazol-2-yl)-2-((4-(4-(m-tolyloxy)quinazolin-2yl)phenyl)amino)acetamides analogs (7a-j) have been synthesized. The synthetic approach exploits a consolidated protocol based on Suzuki coupling reaction on quinazoline ring. The analogs were tested for microbiological activity against eight bacteria (Staphylococcus aureus MTCC 96, Bacillus cereus MTCC 619, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 741, Klebsiella pneumoniae MTCC 109, Salmonella typhi MTCC 733, Proteus vulgaris MTCC 1771 and Shigella flexneri MTCC 1457) and four fungi (Aspergillus niger MTCC 282, Aspergillus fumigatus MTCC 343, Aspergillus clavatus MTCC 1323, and Candida albicans MTCC 183). Some of the synthesized analogs have demonstrated excellent antimicrobial activity (MICs: 3.12-25 μg/mL) as compared with the standards (MICs: 6.25-25 μg/mL). Density Functional Theory (DFT) calculations at the B3LYP/6-31G(d,p) level were performed to predict the molecular structure and electronic properties of the analogs. Further, the binding orientations of the potent analogs were validated by molecular docking studies.
Keywords: Quinazoline, Suzuki coupling, Antimicrobial activity, Molecular docking and DFT.
Letters in Drug Design & Discovery
Title:Design, Synthesis and Computational Studies of New Benzothiazole Substituted Quinazolines as Potential Antimicrobial Agents
Volume: 10 Issue: 10
Author(s): Amit B. Patel, Premlata Kumari, Suban K. Sahoo and Kishor H. Chikhalia
Affiliation:
Keywords: Quinazoline, Suzuki coupling, Antimicrobial activity, Molecular docking and DFT.
Abstract: Some novel N-(benzo[d]thiazol-2-yl)-2-((4-(4-(m-tolyloxy)quinazolin-2yl)phenyl)amino)acetamides analogs (7a-j) have been synthesized. The synthetic approach exploits a consolidated protocol based on Suzuki coupling reaction on quinazoline ring. The analogs were tested for microbiological activity against eight bacteria (Staphylococcus aureus MTCC 96, Bacillus cereus MTCC 619, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 741, Klebsiella pneumoniae MTCC 109, Salmonella typhi MTCC 733, Proteus vulgaris MTCC 1771 and Shigella flexneri MTCC 1457) and four fungi (Aspergillus niger MTCC 282, Aspergillus fumigatus MTCC 343, Aspergillus clavatus MTCC 1323, and Candida albicans MTCC 183). Some of the synthesized analogs have demonstrated excellent antimicrobial activity (MICs: 3.12-25 μg/mL) as compared with the standards (MICs: 6.25-25 μg/mL). Density Functional Theory (DFT) calculations at the B3LYP/6-31G(d,p) level were performed to predict the molecular structure and electronic properties of the analogs. Further, the binding orientations of the potent analogs were validated by molecular docking studies.
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Cite this article as:
B. Patel Amit, Kumari Premlata, K. Sahoo Suban and H. Chikhalia Kishor, Design, Synthesis and Computational Studies of New Benzothiazole Substituted Quinazolines as Potential Antimicrobial Agents, Letters in Drug Design & Discovery 2013; 10 (10) . https://dx.doi.org/10.2174/15701808113109990025
DOI https://dx.doi.org/10.2174/15701808113109990025 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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