Abstract
The development, refinement and increasingly widespread use of high-density DNA microarrays have been important responses to the explosion of sequence information produced by genome science. Principal among the application of microarrays is the large-scale analysis of gene expression, often referred to as expression profiling. The power of this application lies in its ability to determine the expression patterns of thousands of genes in a single experiment. Microarray use is becoming widespread in many biomedical research fields, including the study of carcinogenesis, in which expression profiling has found a number of important applications. Broadly speaking, these applications can be described as gene and pathway discovery, gene functional assignment, and tumor classification. A number of early gene expression studies using tumor cell lines and tumors have shown that DNA microarrays are powerful tools, both for identifying new genes and assigning roles to known genes involved in carcinogenesis as well as for classifying tumors subtypes. In this review, we describe the major types of DNA microarrays, discuss some practical considerations for their use, and present examples of how they are being applied to the investigation of cancer.
Keywords: dna microarray, oligonucleotide microarray
Current Genomics
Title: The Application of DNA Microarrays to the Study of Cancer
Volume: 3 Issue: 4
Author(s): K. Harshman and M. Sanchez-Carbayo
Affiliation:
Keywords: dna microarray, oligonucleotide microarray
Abstract: The development, refinement and increasingly widespread use of high-density DNA microarrays have been important responses to the explosion of sequence information produced by genome science. Principal among the application of microarrays is the large-scale analysis of gene expression, often referred to as expression profiling. The power of this application lies in its ability to determine the expression patterns of thousands of genes in a single experiment. Microarray use is becoming widespread in many biomedical research fields, including the study of carcinogenesis, in which expression profiling has found a number of important applications. Broadly speaking, these applications can be described as gene and pathway discovery, gene functional assignment, and tumor classification. A number of early gene expression studies using tumor cell lines and tumors have shown that DNA microarrays are powerful tools, both for identifying new genes and assigning roles to known genes involved in carcinogenesis as well as for classifying tumors subtypes. In this review, we describe the major types of DNA microarrays, discuss some practical considerations for their use, and present examples of how they are being applied to the investigation of cancer.
Export Options
About this article
Cite this article as:
Harshman K. and Sanchez-Carbayo M., The Application of DNA Microarrays to the Study of Cancer, Current Genomics 2002; 3 (4) . https://dx.doi.org/10.2174/1389202023350372
DOI https://dx.doi.org/10.2174/1389202023350372 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Tumor-Receptor Imaging in Breast Cancer: A Tool for Patient Selection and Response Monitoring
Current Molecular Medicine Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy
Current Medicinal Chemistry Palliative Tumor Control by Trabectedin in Pediatric Advanced Sarcoma
Current Drug Therapy Nanosized Tamoxifen-Porphyrin-Glucose [TPG] Conjugate: Novel Selective Anti-breast-cancer Agent, Synthesis and In Vitro Evaluations
Medicinal Chemistry Porphyrins as Radiosensitizing Agents for Solid Neoplasms
Current Pharmaceutical Design Small Molecule Tyrosine Kinase Inhibitors: Potential Role in Pediatric Malignant Solid Tumors
Current Cancer Drug Targets Cancer Therapy By Targeting Hypoxia-Inducible Factor-1
Current Cancer Drug Targets Repressing the Activity of Protein Kinase CK2 Releases Mitochondria-Mediated Apoptosis in Cancer Cells
Current Drug Targets Nano-Delivery in Pediatric Tumors: Looking Back, Moving Forward
Anti-Cancer Agents in Medicinal Chemistry Blockade of Neoangiogenesis, a New and Promising Technique to Control the Growth of Malignant Tumors and their Metastases
Current Vascular Pharmacology Potential Therapeutic Targets of Curcumin, Most Abundant Active Compound of Turmeric Spice: Role in the Management of Various Types of Cancer
Recent Patents on Anti-Cancer Drug Discovery Identification of Sets of Cytoskeletal Related and Adhesion-related Coding Region Mutations in the TCGA Melanoma Dataset that Correlate with a Negative Outcome
Current Genomics STAT-3 Inhibitors: State of the Art and New Horizons for Cancer Treatment
Current Medicinal Chemistry The Pros and Cons of Targeting Protein Kinase c (PKC) in the Management of Cancer Patients
Current Pharmaceutical Biotechnology Peroxisome Proliferator Activated Receptor α Ligands as Anticancer Drugs Targeting Mitochondrial Metabolism
Current Pharmaceutical Biotechnology Drug Resistance: Challenges to Effective Therapy
Current Cancer Drug Targets Ion Channels as Medicinal Targets of Biological Toxins: The Impact of Automated Patch-Clamp Electrophysiology
Current Topics in Medicinal Chemistry Magnetic Resonance Imaging of Nasopharyngeal Adenoid Hypertrophy in Children Following Bone Marrow Transplantation
Current Medical Imaging Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research
Current Medicinal Chemistry Raman Spectroscopy and Imaging: Promising Optical Diagnostic Tools in Pediatrics
Current Medicinal Chemistry