Abstract
Nanosponges are nanosized novel drug delivery systems which are developed by cross linking the polymers with the cross linking agent. The most commonly used polymer is β-cyclodextrin because it is biodegradable and can form nanosponge having crystalline or amorphous porous structure and spherical shape with uniformity. These nanosponges have the ability to encapsulate lipophillic as well as hydrophilic moiety. The release rate of the drug can be modulated by varying the ratio of polymer to cross linking agent. Nanosponges are very minute structures such that they can be used for targeting the drug to the specific site by conjugating the ligands onto their surface. Nanosponges can be employed to enhance the aqueous solubility of poorly water soluble drugs, improve bioavailability, and protect photo sensitive drugs, for sustained release and for site specific drug delivery. Nanosponge technology is also employed in the fields other than pharmacy and medicine like water purification, for pollution free environment, in gas storage and also in agriculture. It is a unique and multifunctional technology, considered to be suitable for the drug delivery.
Keywords: β-cyclodextrin, bioavailability, cross-linking, nanosponge, sustained drug delivery.
Drug Delivery Letters
Title:Nanosponge: A Novel Carrier for Drug Delivery
Volume: 3 Issue: 3
Author(s): Rehana Ansari, Rachna Maheshwari, Shikha Jain, Suresh C. Mahajan and Vikas Jain
Affiliation:
Keywords: β-cyclodextrin, bioavailability, cross-linking, nanosponge, sustained drug delivery.
Abstract: Nanosponges are nanosized novel drug delivery systems which are developed by cross linking the polymers with the cross linking agent. The most commonly used polymer is β-cyclodextrin because it is biodegradable and can form nanosponge having crystalline or amorphous porous structure and spherical shape with uniformity. These nanosponges have the ability to encapsulate lipophillic as well as hydrophilic moiety. The release rate of the drug can be modulated by varying the ratio of polymer to cross linking agent. Nanosponges are very minute structures such that they can be used for targeting the drug to the specific site by conjugating the ligands onto their surface. Nanosponges can be employed to enhance the aqueous solubility of poorly water soluble drugs, improve bioavailability, and protect photo sensitive drugs, for sustained release and for site specific drug delivery. Nanosponge technology is also employed in the fields other than pharmacy and medicine like water purification, for pollution free environment, in gas storage and also in agriculture. It is a unique and multifunctional technology, considered to be suitable for the drug delivery.
Export Options
About this article
Cite this article as:
Ansari Rehana, Maheshwari Rachna, Jain Shikha, C. Mahajan Suresh and Jain Vikas, Nanosponge: A Novel Carrier for Drug Delivery, Drug Delivery Letters 2013; 3 (3) . https://dx.doi.org/10.2174/22103031113039990004
DOI https://dx.doi.org/10.2174/22103031113039990004 |
Print ISSN 2210-3031 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-304X |
Call for Papers in Thematic Issues
Nanomaterial Assisted Targeted Therapies for Chronic Disorders- Preclinical to Clinical Outcomes
In recent years, the integration of nanomaterials into therapeutic strategies has emerged as a promising avenue in the pursuit of more effective treatments for chronic disorders. This dynamic field, explored in the context of "Nanomaterial Assisted Targeted Therapies for Chronic Disorders - Preclinical to Clinical Outcomes," seeks to bridge the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Role of E-Cadherin Down-Regulation in Oral Cancer: CDH1 Gene Expression and Epigenetic Blockage
Current Cancer Drug Targets Biological Interfacial Engineering for Metastatic Cancer Diagnosis and Intervention
Current Medicinal Chemistry Enhanced Activity of pSTAT-3 Ser-727 in Functional Endothelial Cells Under Calcifying Conditions
Current Chemical Biology Cross-Talk Between the Androgen Receptor and the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer
Current Cancer Drug Targets Immunotherapy of Cancer Based on DC-Tumor Fusion Vaccine
Current Immunology Reviews (Discontinued) Silence of the Genes: A Targeted Approach to the Suppression of Specific Genes in Human Disease Using Small Interfering RNA (siRNA)
Current Genomics Molecular Targeted Approaches to Cancer Therapy and Prevention Using Chalcones
Current Cancer Drug Targets Recent Advances in the Development of Nonpeptide Somatostatin Receptor Ligands
Mini-Reviews in Medicinal Chemistry Targeted Drug Delivery System for Platinum-based Anticancer Drugs
Mini-Reviews in Medicinal Chemistry Can PET Imaging Facilitate Optimization of Cancer Therapies?
Current Pharmaceutical Design Enhanced Free Radical Status of Cancer Cells Success and Failure of Prooxidant/Antioxidant Treatment
Current Signal Transduction Therapy Multiligand Endocytosis and Congenital Defects: Roles of Cubilin, Megalin and Amnionless
Current Pharmaceutical Design Targeting the Tumor Stroma with Peroxisome Proliferator Activated Receptor (PPAR) Agonists
Anti-Cancer Agents in Medicinal Chemistry Melatonin as a Selective Estrogen Enzyme Modulator
Current Cancer Drug Targets Cyclin-Dependent Kinase-2 as a Target for Cancer Therapy: Progress in the Development of CDK2 Inhibitors as Anti-Cancer Agents
Current Medicinal Chemistry Chitosan Nanoparticles: An Approbative System for the Delivery of Herbal Bioactives
The Natural Products Journal Use of Radiopharmaceuticals for Diagnosis, Treatment, and Follow-Up of Differentiated Thyroid Carcinoma
Anti-Cancer Agents in Medicinal Chemistry Mitochondrial Permeability Transition as Target of Anticancer Drugs
Current Pharmaceutical Design Nonviral Gene Therapy
Current Gene Therapy Intracellular Fate of Peptide-Mediated Delivered Cargoes
Current Pharmaceutical Design