Abstract
Biopharmaceutical properties together with potency contribute critically towards clinical efficacy of the drugs by influencing the dissolution and bioavailability. The aim of this study was to develop an amphiphilic phyto-phospholipid complex in order to enhance the delivery of poorly soluble rutin. The rutin-phospholipid complex (Ru-PLc) was prepared and investigated for various physico-chemical parameters like drug loading, infrared absorption (FTIR), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), scanning electron microscopy (SEM), aqueous/ n-octanol solubility and dissolution study. The in vitro anti-oxidant activity was also studied. In the SEM, Ru-PLc was found fluffy and porous with rough surface morphology. FTIR, DSC and XRPD data confirmed the formation of phospholipid complex. The water/ noctanol solubility of rutin was improved from 2.88 to 45.71 μg/ ml and 68.17 to 245.18 μg/ ml, respectively in the complex. The improved dissolution was shown by the phospholipid complex at different pH buffers. The antioxidant activity indicated that, the bioactivity of rutin was maintained even after being complexed with the phospholipid. Based on the results, it can be concluded that the phospholipid complex may be considered as a promising drug delivery system for improving the overall absorption and bioavailability of the rutin molecule.
Keywords: Rutin, Phosphatidylcholine, Phospholipid complex, Chromatographic analysis, DSC, X-RPD, Antioxidant assay
Current Drug Delivery
Title:Rutin-Phospholipid Complex: An Innovative Technique in Novel Drug Delivery System- NDDS
Volume: 9 Issue: 3
Author(s): Devendra Singh, M. S.M. Rawat, Ajay Semalty and Mona Semalty
Affiliation:
Keywords: Rutin, Phosphatidylcholine, Phospholipid complex, Chromatographic analysis, DSC, X-RPD, Antioxidant assay
Abstract: Biopharmaceutical properties together with potency contribute critically towards clinical efficacy of the drugs by influencing the dissolution and bioavailability. The aim of this study was to develop an amphiphilic phyto-phospholipid complex in order to enhance the delivery of poorly soluble rutin. The rutin-phospholipid complex (Ru-PLc) was prepared and investigated for various physico-chemical parameters like drug loading, infrared absorption (FTIR), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), scanning electron microscopy (SEM), aqueous/ n-octanol solubility and dissolution study. The in vitro anti-oxidant activity was also studied. In the SEM, Ru-PLc was found fluffy and porous with rough surface morphology. FTIR, DSC and XRPD data confirmed the formation of phospholipid complex. The water/ noctanol solubility of rutin was improved from 2.88 to 45.71 μg/ ml and 68.17 to 245.18 μg/ ml, respectively in the complex. The improved dissolution was shown by the phospholipid complex at different pH buffers. The antioxidant activity indicated that, the bioactivity of rutin was maintained even after being complexed with the phospholipid. Based on the results, it can be concluded that the phospholipid complex may be considered as a promising drug delivery system for improving the overall absorption and bioavailability of the rutin molecule.
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Cite this article as:
Singh Devendra, S.M. Rawat M., Semalty Ajay and Semalty Mona, Rutin-Phospholipid Complex: An Innovative Technique in Novel Drug Delivery System- NDDS, Current Drug Delivery 2012; 9 (3) . https://dx.doi.org/10.2174/156720112800389070
DOI https://dx.doi.org/10.2174/156720112800389070 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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