Abstract
In this review we shall attempt to summarize the literature published on the high responders/low responders animal model of drug addiction. This model is based on the locomotor activity of rats in the mild stress of a novel environment. Rats that exhibit high rates of exploratory behaviours are deemed high responders (HR) and rats that exhibit low exploratory behaviours are deemed low responders (LR). Interestingly, the rate of these exploratory behaviours predicts the response of these animals to drugs of abuse. In this manuscript we will review the behavioural and physiological differences between HR and LR rats in response to d-amphemtamine, cocaine, morphine, alcohol and nicotine.
Keywords: behavioural sensitization, d-amphetamine, Conditioned Place Preference (CPP), Acute Locomotor Response, Morphine, Drug Abuse
CNS & Neurological Disorders - Drug Targets
Title: Individual Differences in Vulnerability to Drug Abuse: The High Responders/Low Responders Model
Volume: 5 Issue: 5
Author(s): Mohamed Kabbaj
Affiliation:
Keywords: behavioural sensitization, d-amphetamine, Conditioned Place Preference (CPP), Acute Locomotor Response, Morphine, Drug Abuse
Abstract: In this review we shall attempt to summarize the literature published on the high responders/low responders animal model of drug addiction. This model is based on the locomotor activity of rats in the mild stress of a novel environment. Rats that exhibit high rates of exploratory behaviours are deemed high responders (HR) and rats that exhibit low exploratory behaviours are deemed low responders (LR). Interestingly, the rate of these exploratory behaviours predicts the response of these animals to drugs of abuse. In this manuscript we will review the behavioural and physiological differences between HR and LR rats in response to d-amphemtamine, cocaine, morphine, alcohol and nicotine.
Export Options
About this article
Cite this article as:
Kabbaj Mohamed, Individual Differences in Vulnerability to Drug Abuse: The High Responders/Low Responders Model, CNS & Neurological Disorders - Drug Targets 2006; 5 (5) . https://dx.doi.org/10.2174/187152706778559318
DOI https://dx.doi.org/10.2174/187152706778559318 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
In Vitro and Ex Vivo Characterization of Sigma-1 and Sigma-2 Receptors: Agonists and Antagonists in Biological Assays
Central Nervous System Agents in Medicinal Chemistry Heme Oxygenase-1 against Vascular Insufficiency: Roles of Atherosclerotic Disorders
Current Pharmaceutical Design Diabetes Mellitus to Neurodegenerative Disorders: Is Oxidative Stress Fueling the Flame?
CNS & Neurological Disorders - Drug Targets Acute Lymphoblastic Leukemia and Regulatory T cells: Biomarkers and Immunopathogenesis
Current Immunology Reviews (Discontinued) Prevention of Serum Albumin Glycation/Fibrillation by β-Cyclodextrin Functionalized Magnetic Nanoparticles
Protein & Peptide Letters Editorial [Hot Topic: Compliance, Adherence and Concordance in Medicine Taking of Psychiatric Patients (Guest Editor: Carlos De las Cuevas)]
Current Clinical Pharmacology Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Neurotransmitter Regulation of Adult Neurogenesis: Putative Therapeutic Targets
CNS & Neurological Disorders - Drug Targets Children with Medical Complexity: Forwarding a Policy Agenda
Current Pediatric Reviews MiR-106a Associated with Diabetic Peripheral Neuropathy Through the Regulation of 12/15-LOX-meidiated Oxidative/Nitrative Stress
Current Neurovascular Research Inflammatory and Vascular Alterations in Sepsis: The Role of Nitric Oxide- Dependent Mechanisms
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Recent Advances in the Rationale Design of GPER Ligands
Current Medicinal Chemistry The Endocannabinoid System and the Treatment of Mood and Anxiety Disorders
CNS & Neurological Disorders - Drug Targets Adenosine in the Central Nervous System: Effects on Neurotransmission and Neuroprotection
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Preliminary Studies on Optimization of Anti-Parkinson Drug Loaded Lipid Nanoparticles Enriched Hydrogel Formulations for Management of Parkinson’s Disease
Current Nanomedicine Cytokines: From Gut Inflammation to Colorectal Cancer
Current Drug Targets Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders
CNS & Neurological Disorders - Drug Targets Characterisation of Mitochondrial DNA Deletions by Long-PCR in Central Nervous System Regions of Young, Middle- and Old-aged Rats
Current Aging Science Studies on Novel Pyridine and 2-pyridone Derivatives of N-arylpiperazine as α-adrenoceptor Ligands
Medicinal Chemistry Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches
CNS & Neurological Disorders - Drug Targets