Abstract
Decreased Mg intake and low Mg status have been associated with a number of major health concerns such as diabetes mellitus type II, coronary heart disease, and osteoporosis. While information on Mg intake is available, relatively little is known on dietary factors influencing Mg bioavailability. While it is established that Mg absorption is based on a combination of a non-saturable and a saturable pathway, the nature of especially the latter mechanism is not well understood. Recently, stable isotopes have improved techniques available for the determination of Mg absorption from single test meals or supplements. Some inorganic Mg forms such as MgO seem of limited solubility in the intestine, suggesting low bioavailability. Recent studies have further added evidence that some commonly consumed dietary compounds, such as phytate and oxalate, can inhibit Mg absorption, presumably via complexation, preventing absorption from the small intestine. Phytate for example has been shown to decrease Mg absorption by up to 60%, in a dose dependent manner. On the other hand, fermentable dietary fibre, such as fructo-oligosaccharides, have been demonstrated to increase Mg absorption in humans by 10-25%, even though the underlying mechanisms remain to be elucidated. Future studies to investigate factors impacting Mg absorption are warranted.
Keywords: Mg-absorption, small intestine, large intestine, protein transporters, dietary fibre, chelates
Current Nutrition & Food Science
Title: Dietary Factors Influencing Magnesium Absorption in Humans
Volume: 4 Issue: 1
Author(s): Torsten Bohn
Affiliation:
Keywords: Mg-absorption, small intestine, large intestine, protein transporters, dietary fibre, chelates
Abstract: Decreased Mg intake and low Mg status have been associated with a number of major health concerns such as diabetes mellitus type II, coronary heart disease, and osteoporosis. While information on Mg intake is available, relatively little is known on dietary factors influencing Mg bioavailability. While it is established that Mg absorption is based on a combination of a non-saturable and a saturable pathway, the nature of especially the latter mechanism is not well understood. Recently, stable isotopes have improved techniques available for the determination of Mg absorption from single test meals or supplements. Some inorganic Mg forms such as MgO seem of limited solubility in the intestine, suggesting low bioavailability. Recent studies have further added evidence that some commonly consumed dietary compounds, such as phytate and oxalate, can inhibit Mg absorption, presumably via complexation, preventing absorption from the small intestine. Phytate for example has been shown to decrease Mg absorption by up to 60%, in a dose dependent manner. On the other hand, fermentable dietary fibre, such as fructo-oligosaccharides, have been demonstrated to increase Mg absorption in humans by 10-25%, even though the underlying mechanisms remain to be elucidated. Future studies to investigate factors impacting Mg absorption are warranted.
Export Options
About this article
Cite this article as:
Bohn Torsten, Dietary Factors Influencing Magnesium Absorption in Humans, Current Nutrition & Food Science 2008; 4 (1) . https://dx.doi.org/10.2174/157340108783497427
DOI https://dx.doi.org/10.2174/157340108783497427 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
Call for Papers in Thematic Issues
Bioactive compounds, functional foods, metabolism, and health
Nutrition, metabolism, and their intervention strategies have become focal points of interest in the study of metabolic syndrome and health. Bioactive compounds, phytochemicals, and functional foods play crucial roles in modulating metabolic processes and improving human health. Moreover, the composition of the gut microbiome is also believed to be closely ...read more
Functional Foods in Human Health and Beyond
Foods are important source of nutrients including carbohydrates, proteins, lipids and other minerals. Furthermore, the functional foods are those agents that have additional components that are essential supports to the body in terms of antioxidant and pharmacologically active agents. The predominant functional foods are of plant in origin, whereas some ...read more
Harnessing Bioactive Compounds from Food Waste: Sustainable Extraction Strategies and Health Applications
Food waste presents a significant challenge across the postharvest cycle, from agricultural production to distribution. However, within this waste lies a treasure trove of bioactive chemicals that hold immense potential for nutraceuticals, functional foods, and postharvest additives, including antimicrobials. Various extraction methods, such as solvent extraction (SE), supercritical fluid extraction ...read more
Natural Bioactive Compounds Derivatives in Nutraceutical and Food Science
In the last years, plants have been widely used for their numerous properties and now there is growing interest in the study of classes of compounds obtained from plant species or derived from them. The importance of these natural compounds lies in their important therapeutic purposes, and in their capability ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Hepatic PPARs: Their Role in Liver Physiology, Fibrosis and Treatment
Current Medicinal Chemistry Editorial (Hot Topic: Vitamin D Deficiency and Critical Illness)
Inflammation & Allergy - Drug Targets (Discontinued) Neuronal and Vascular Oxidative Stress in Alzheimers Disease
Current Neuropharmacology Autoimmunity in Alzheimers Disease as Evidenced by Plasma Immunoreactivity Against RAGE and Aβ42: Complication of Diabetes
Current Alzheimer Research Pharmacological Regulation of Dyslipoproteinaemia in Insulin Resistant States
Current Vascular Pharmacology Population Approaches for Detecting Glucose Disorders
Current Diabetes Reviews Cardiac Protection via Metabolic Modulation: An Emerging Role for Incretin-Based Therapies?
Cardiovascular & Hematological Agents in Medicinal Chemistry Improving Red Blood Cell K-Uptake and its Impact on O2/CO2 Exchange, and NO-Generation in Microvascular CHD: A Novel Therapeutic Approach
Recent Patents on Cardiovascular Drug Discovery Innate Immunity, Toll-Like Receptors, and Diabetes
Current Immunology Reviews (Discontinued) Pulmonary Hypertension: Current Therapy and Future Prospects
Cardiovascular & Hematological Agents in Medicinal Chemistry Pulmonary Neuroendocrine Cell System in Health and Disease
Current Respiratory Medicine Reviews Cigarette Smoking and Angiogenesis: What is the Role of Endothelial Progenitor Cells?
Current Angiogenesis (Discontinued) A<sub>3</sub> Adenosine Receptor: A Plausible Therapeutic Target for Cardio-Protection in Diabetes
Recent Patents on Cardiovascular Drug Discovery Angiogenesis as a Therapeutic Target in Arthritis: Lessons from Oncology
Current Pharmaceutical Design Role of Vasa Vasorum in Arterial Disease: A Re-emerging Factor
Current Cardiology Reviews Risk Factors of Alzheimers Disease Among Iranian Population
Current Alzheimer Research Choosing a Revascularization Strategy in Patients with Diabetes and Stable Coronary Artery Disease: A Complex Decision
Current Cardiology Reviews The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson's Disease Model
CNS & Neurological Disorders - Drug Targets Editorial: Inflammation and Heart Diseases
Current Pharmaceutical Design Editorial [Hot Topic: Oxidative Stress Induced-Metabolic Imbalance, Mitochondrial Failure, And Cellular Hypoperfusion As Primary Pathogenetic Factors For The Development Of Alzheimer Disease Which Can Be Used As An Alternate And Successful Drug Treatment Strategy: Past, Present And Future (Guest Editor: Gjumrakch Aliev)]
CNS & Neurological Disorders - Drug Targets