Abstract
While it has been known for some time that CD93 regulates several processes involved in innate immunity and inflammation including phagocytosis and adhesion, the function of CD93 in disease progression is only now being elucidated. Recent in vivo studies in mice, and genome wide studies in mice and humans, have provided clues about its molecular function. Following a comprehensive review of CD93 expression patterns, this review will focus on recent findings over the last three years that address the putative function of CD93 in inflammation and innate immunity.
Keywords: CD93, inflammation, innate immunity, Group XIV, adhesion, AA4.1, MMP cleavage site, microarray studies, ischemia, cancer
Current Drug Targets
Title: CD93: Recent Advances and Implications in Disease
Volume: 13 Issue: 3
Author(s): Mallary C. Greenlee-Wacker, Manuel D. Galvan and Suzanne S. Bohlson
Affiliation:
Keywords: CD93, inflammation, innate immunity, Group XIV, adhesion, AA4.1, MMP cleavage site, microarray studies, ischemia, cancer
Abstract: While it has been known for some time that CD93 regulates several processes involved in innate immunity and inflammation including phagocytosis and adhesion, the function of CD93 in disease progression is only now being elucidated. Recent in vivo studies in mice, and genome wide studies in mice and humans, have provided clues about its molecular function. Following a comprehensive review of CD93 expression patterns, this review will focus on recent findings over the last three years that address the putative function of CD93 in inflammation and innate immunity.
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Cite this article as:
C. Greenlee-Wacker Mallary, D. Galvan Manuel and S. Bohlson Suzanne, CD93: Recent Advances and Implications in Disease, Current Drug Targets 2012; 13 (3) . https://dx.doi.org/10.2174/138945012799424651
DOI https://dx.doi.org/10.2174/138945012799424651 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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