Abstract
Gene therapy is an important tool in the treatment of many diseases involving malfunctioning of deoxyribo nucleic acid (DNA). Development of various techniques for efficiently transferring and expression of recombinant DNA or ribonucleic acid (RNA) at target site is a significant challenge. Viral vectors which have been used classically have a number of restrictions due to their induced toxicity and immunogenicity, the limited size of DNA that can be carried, the lack of specificity and the high cost of production. To overcome these problems nonviral vectors like nanoparticles, dendrimers, molecular conjugates, liposomes, microbubbles etc. are being explored. This review encompasses the details of these nonviral vectors.
Keywords: Efficiency, gene delivery, nonviral, transfection, vector, viral, Nanoparticles, Dendriplexes, Molecular Conjugates, Microbubbles
Current Drug Therapy
Title: Advanced Vectors for Gene Delivery
Volume: 6 Issue: 4
Author(s): Rajashree Hirlekar, Pramod Jagtap and Vilasrao Kadam
Affiliation:
Keywords: Efficiency, gene delivery, nonviral, transfection, vector, viral, Nanoparticles, Dendriplexes, Molecular Conjugates, Microbubbles
Abstract: Gene therapy is an important tool in the treatment of many diseases involving malfunctioning of deoxyribo nucleic acid (DNA). Development of various techniques for efficiently transferring and expression of recombinant DNA or ribonucleic acid (RNA) at target site is a significant challenge. Viral vectors which have been used classically have a number of restrictions due to their induced toxicity and immunogenicity, the limited size of DNA that can be carried, the lack of specificity and the high cost of production. To overcome these problems nonviral vectors like nanoparticles, dendrimers, molecular conjugates, liposomes, microbubbles etc. are being explored. This review encompasses the details of these nonviral vectors.
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Cite this article as:
Hirlekar Rajashree, Jagtap Pramod and Kadam Vilasrao, Advanced Vectors for Gene Delivery, Current Drug Therapy 2011; 6 (4) . https://dx.doi.org/10.2174/157488511798109600
DOI https://dx.doi.org/10.2174/157488511798109600 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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