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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

The Role of Nitric oxide (NO) Donors in the Treatment of Male Infertility

Author(s): Edoardo Pozzi, Omer Onur Cakir and Asif Muneer*

Volume 27, Issue 24, 2021

Published on: 12 November, 2020

Page: [2784 - 2789] Pages: 6

DOI: 10.2174/1381612826666201112144828

Price: $65


Male infertility is a global problem and the number of men suffering from this condition has increased dramatically over the last decade. Currently, approximately 10–15% of couples have been affected by this worldwide. Although this is a crucial problem, treatment options are limited and sometimes even ineffective. In order to arrest this worrisome increase, the development of new treatment strategies has become fundamental. Redox regulation driven by NO in reproductive biology represents a novel pathway in male infertility and it plays a crucial role in maintaining normal fertilisation capacity. Compelling evidence states that ROS synthesis and degradation should be in perfect balance and tightly regulated by endogenous and exogenous antioxidant enzymes. NO donor drugs might play a beneficial role in restoring this fragile equilibrium and have shown great potential in ameliorating overall fertilisation capacity.

Keywords: Nitric oxide, male infertility, reactive oxygen species, treatment options, fertilisation capacity, reproductive biology.

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