Abstract
Male infertility is a global problem and the number of men suffering from this condition has increased dramatically over the last decade. Currently, approximately 10–15% of couples have been affected by this worldwide. Although this is a crucial problem, treatment options are limited and sometimes even ineffective. In order to arrest this worrisome increase, the development of new treatment strategies has become fundamental. Redox regulation driven by NO in reproductive biology represents a novel pathway in male infertility and it plays a crucial role in maintaining normal fertilisation capacity. Compelling evidence states that ROS synthesis and degradation should be in perfect balance and tightly regulated by endogenous and exogenous antioxidant enzymes. NO donor drugs might play a beneficial role in restoring this fragile equilibrium and have shown great potential in ameliorating overall fertilisation capacity.
Keywords: Nitric oxide, male infertility, reactive oxygen species, treatment options, fertilisation capacity, reproductive biology.
Current Pharmaceutical Design
Title:The Role of Nitric oxide (NO) Donors in the Treatment of Male Infertility
Volume: 27 Issue: 24
Author(s): Edoardo Pozzi, Omer Onur Cakir and Asif Muneer*
Affiliation:
- Institute of Andrology, University College London Hospital, London,United Kingdom
Keywords: Nitric oxide, male infertility, reactive oxygen species, treatment options, fertilisation capacity, reproductive biology.
Abstract: Male infertility is a global problem and the number of men suffering from this condition has increased dramatically over the last decade. Currently, approximately 10–15% of couples have been affected by this worldwide. Although this is a crucial problem, treatment options are limited and sometimes even ineffective. In order to arrest this worrisome increase, the development of new treatment strategies has become fundamental. Redox regulation driven by NO in reproductive biology represents a novel pathway in male infertility and it plays a crucial role in maintaining normal fertilisation capacity. Compelling evidence states that ROS synthesis and degradation should be in perfect balance and tightly regulated by endogenous and exogenous antioxidant enzymes. NO donor drugs might play a beneficial role in restoring this fragile equilibrium and have shown great potential in ameliorating overall fertilisation capacity.
Export Options
About this article
Cite this article as:
Pozzi Edoardo , Cakir Onur Omer and Muneer Asif*, The Role of Nitric oxide (NO) Donors in the Treatment of Male Infertility, Current Pharmaceutical Design 2021; 27 (24) . https://dx.doi.org/10.2174/1381612826666201112144828
DOI https://dx.doi.org/10.2174/1381612826666201112144828 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Effects of Antihypertensive Therapy on Haemostatic Parameters
Current Pharmaceutical Design QSAR of Antitrypanosomal Activities of Polyphenols and their Analogues Using Multiple Linear Regression and Artificial Neural Networks
Combinatorial Chemistry & High Throughput Screening Treatment of Tachycardia in Hypertension: Where Do We Stand Now?
Current Hypertension Reviews Clopidogrel, Aspirin and Proton Pump Inhibition after Percutaneous Valve Implants: An Update
Current Pharmaceutical Design New Insight Into A1 Adenosine Receptors in Diabetes Treatment
Current Pharmaceutical Design Enzymatic regulation and functional relevance of NOX5
Current Pharmaceutical Design Angiotensin II and the Cardiac Complications of Diabetes Mellitus
Current Pharmaceutical Design Overview of Green Tea Interaction with Cardiovascular Drugs
Current Pharmaceutical Design Superior Neuroprotective Effects of Cerebrolysin in Nanoparticle-Induced Exacerbation of Hyperthermia-Induced Brain Pathology
CNS & Neurological Disorders - Drug Targets Melanogenesis and Melanosome Transportation Modulators from Medicinal Plants
Letters in Drug Design & Discovery Inflamm-ageing and senescence in gout: the tale of an old king’s disease.
Current Aging Science Ethical and Social Issues in Pharmacogenomics Testing
Current Pharmaceutical Design Expression and Function of Anti-Inflammatory Interleukins: The Other Side of the Vascular Response to Injury
Current Vascular Pharmacology Biological Therapies: Effects of Proinflammatory Pathways and their Inhibition on the Myocardium of Rheumatoid Athritis Patients
Current Medicinal Chemistry Large Unrepaired Aortopulmonary Window Presenting in Adulthood
Current Cardiology Reviews Centralized and Local Color Doppler Ultrasound Reading Agreement for Diagnosis of the Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis
Current Neurovascular Research Nutritional and Therapeutic Potential of Garlic and Onion (Allium sp.)
Current Nutrition & Food Science Cardiovascular Manifestations of COVID-19
Current Cardiology Reviews Dyslipidaemia, Hypercoagulability and the Metabolic Syndrome
Current Vascular Pharmacology Torasemide for the Treatment of Heart Failure
Cardiovascular & Hematological Disorders-Drug Targets