Abstract
Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.
Keywords: Extracellular matrix, myocardial infarction, tissue engineering, cardiac repair, angiogenesis
Current Vascular Pharmacology
Title:Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair
Volume: 10 Issue: 3
Author(s): Shirley S. Mihardja and Randall J. Lee
Affiliation:
Keywords: Extracellular matrix, myocardial infarction, tissue engineering, cardiac repair, angiogenesis
Abstract: Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.
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Cite this article as:
S. Mihardja Shirley and J. Lee Randall, Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair, Current Vascular Pharmacology 2012; 10 (3) . https://dx.doi.org/10.2174/157016112799959341
DOI https://dx.doi.org/10.2174/157016112799959341 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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