Current Vascular Pharmacology

Dimitri P. Mikhailidis  
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG


Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair

Author(s): Shirley S. Mihardja and Randall J. Lee

Affiliation: University of California San Francisco, Box 1354, San Francisco, CA 94143, USA.

Keywords: Extracellular matrix, myocardial infarction, tissue engineering, cardiac repair, angiogenesis


Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.

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Article Details

Page: [342 - 346]
Pages: 5
DOI: 10.2174/157016112799959341