Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair
Shirley S. Mihardja and Randall J. Lee
Affiliation: University of California San Francisco, Box 1354, San Francisco, CA 94143, USA.
Keywords: Extracellular matrix, myocardial infarction, tissue engineering, cardiac repair, angiogenesis
Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies
have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction.
In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using
an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able
to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially
new non-invasive strategy for repairing damaged cardiac tissue.
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