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Current Vascular Pharmacology
ISSN (Print): 1570-1611
ISSN (Online): 1875-6212
VOLUME: 10
ISSUE: 3
DOI: 10.2174/157016112799959341      Price:  $58









Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair

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Author(s): Shirley S. Mihardja and Randall J. Lee
Pages 342-346 (5)
Abstract:
Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.
Keywords:
Extracellular matrix, myocardial infarction, tissue engineering, cardiac repair, angiogenesis
Affiliation:
University of California San Francisco, Box 1354, San Francisco, CA 94143, USA.