Abstract
Intracellular calcium homeostasis plays a fundamental role in the electric and mechanical function of the heart by modulating action potential pattern and duration, by linking cell membrane depolarization to myocardial contraction and by regulating cardiac automaticity. Abnormalities of intracellular calcium regulation disrupt the electrophysiological properties of the heart and create an arrhythmogenic milieu, which promotes atrial and ventricular arrhythmogenesis and impairs cardiac automaticity and atrioventricular conduction. In this brief review, we summarize the basic genetic, molecular and electrophysiological mechanisms linking inherited or acquired intracellular Ca2+ dysregulation to arrhythmogenesis.
Keywords: Calcium, arrhythmia, pathophysiology, pathogenesis.
Medicinal Chemistry
Title:Calcium Handling and Arrhythmogenesis
Volume: 12 Issue: 2
Author(s): Georgios C. Bompotis, Loukas K. Pappas, Christos Angelidis, Charalampos Kossyvakis, Georgios Giannopoulos and Spyridon Deftereos
Affiliation:
Keywords: Calcium, arrhythmia, pathophysiology, pathogenesis.
Abstract: Intracellular calcium homeostasis plays a fundamental role in the electric and mechanical function of the heart by modulating action potential pattern and duration, by linking cell membrane depolarization to myocardial contraction and by regulating cardiac automaticity. Abnormalities of intracellular calcium regulation disrupt the electrophysiological properties of the heart and create an arrhythmogenic milieu, which promotes atrial and ventricular arrhythmogenesis and impairs cardiac automaticity and atrioventricular conduction. In this brief review, we summarize the basic genetic, molecular and electrophysiological mechanisms linking inherited or acquired intracellular Ca2+ dysregulation to arrhythmogenesis.
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Bompotis C. Georgios, Pappas K. Loukas, Angelidis Christos, Kossyvakis Charalampos, Giannopoulos Georgios and Deftereos Spyridon, Calcium Handling and Arrhythmogenesis, Medicinal Chemistry 2016; 12 (2) . https://dx.doi.org/10.2174/157340641202160209102839
DOI https://dx.doi.org/10.2174/157340641202160209102839 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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