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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 8
ISSUE: 5
DOI: 10.2174/157018011795514221      Price:  $58









Evaluation of N-(2-Thienylidene)amines, N-(2-Hydroxybenzylidene)amines and 3-Iminoindolin-2-ones as Antileishmanial Agents

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Author(s): Yasser M.S.A. Al-Kahraman, Girija S. Singh and Masoom Yasinzai
Pages 491-495 (5)
Abstract:
The paper describes the synthesis and antileishmanial activity of N-substituted imines, obtained from the reactions of primary amines with three biologically important aldehydes/ketones, thiophene-2-carbaldehyde, 2- hydroxybenzaldehyde (salicylaldehyde) and indoline-2,3-dione. Of the fourteen compounds screened from three classes, five compounds showed significant antileishmanial activity. Among the three classes of imines, the class of N-(2- thienylidene)amines showed much better activity than the other two classes. N-(2-Thienylidene)benzhydrylamine showed IC50 value of 0.51 μg/ml. The effect of substituents on the bioactivity is discussed.
Keywords:
Antileishmanial, Imines, Indoline-2,3-dione, Leishmaniasis, Thiophene-2-carbaldehyde, Salicylaldehyde, N-(2-Thienylidene)amines, Hydroxybenzylidene amines, 3-Iminoindolin-2-ones, Antileishmanial Agents, antileishmanial activity, NMR, N-aromatic imines, hydroxybenzaldehyde
Affiliation:
Chemistry Department, University of Botswana, P/Bag: 0022, Gaborone, Botswana.