Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Email: lddd@benthamscience.org


Evaluation of N-(2-Thienylidene)amines, N-(2-Hydroxybenzylidene)amines and 3-Iminoindolin-2-ones as Antileishmanial Agents

Author(s): Yasser M.S.A. Al-Kahraman, Girija S. Singh and Masoom Yasinzai

Affiliation: Chemistry Department, University of Botswana, P/Bag: 0022, Gaborone, Botswana.


The paper describes the synthesis and antileishmanial activity of N-substituted imines, obtained from the reactions of primary amines with three biologically important aldehydes/ketones, thiophene-2-carbaldehyde, 2- hydroxybenzaldehyde (salicylaldehyde) and indoline-2,3-dione. Of the fourteen compounds screened from three classes, five compounds showed significant antileishmanial activity. Among the three classes of imines, the class of N-(2- thienylidene)amines showed much better activity than the other two classes. N-(2-Thienylidene)benzhydrylamine showed IC50 value of 0.51 μg/ml. The effect of substituents on the bioactivity is discussed.

Keywords: Antileishmanial, Imines, Indoline-2,3-dione, Leishmaniasis, Thiophene-2-carbaldehyde, Salicylaldehyde, N-(2-Thienylidene)amines, Hydroxybenzylidene amines, 3-Iminoindolin-2-ones, Antileishmanial Agents, antileishmanial activity, NMR, N-aromatic imines, hydroxybenzaldehyde

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Article Details

Page: [491 - 495]
Pages: 5
DOI: 10.2174/157018011795514221
Price: $58