Coupling Reaction of Acid Chlorides with Terminal Alkynes Catalyzed by Diatomite-Supported Palladium(II) Salophen Complex

Author(s): Mohammad Bakherad, Ali Keivanloo, Bahram Bahramian, Zahra Kalantar, Faezeh N. Ashrafi.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 5 , 2011

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Abstract:

A highly-efficient method for the copper- and solvent-free coupling reaction of acid chlorides and terminal alkynes catalyzed by diatomite-supported palladium(II) salophen complex is described. Acid chlorides are easily coupled with terminal alkynes, giving good to high yields in the presence of a low catalyst loading (1 mol% Pd) in DIEA at room temperature under aerobic conditions. After centrifugation, the supported catalyst is able to be recycled and reused for several times with only a slight decrease in activity.

Keywords: Copper-free, sonogashira reaction, supported catalyst, acid chlorides, alkynyl, acylation, polystyrene-supported, bidentate, phosphine, palladium

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Article Details

VOLUME: 8
ISSUE: 5
Year: 2011
Page: [364 - 367]
Pages: 4
DOI: 10.2174/157017811795685117
Price: $58

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